Changes in cerebral morphology consequent to peripheral autonomic denervation.

Détails

ID Serval
serval:BIB_34C296759C65
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Changes in cerebral morphology consequent to peripheral autonomic denervation.
Périodique
Neuroimage
Auteur(s)
Critchley H.D., Good C.D., Ashburner J., Frackowiak R.S., Mathias C.J., Dolan R.J.
ISSN
1053-8119 (Print)
ISSN-L
1053-8119
Statut éditorial
Publié
Date de publication
2003
Volume
18
Numéro
4
Pages
908-916
Langue
anglais
Notes
Publication types: Clinical Trial ; Controlled Clinical Trial ; Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Pure autonomic failure (PAF) is characterized by an acquired, selective, peripheral denervation of the autonomic nervous system. Patients with PAF fail to generate bodily states of arousal via the autonomic nervous system in response to physical or cognitive effort. We used voxel-based morphometry to test the hypothesis that changes in the morphology of brain regions involved in autonomic control would arise as a consequence to the longstanding absence of peripheral autonomic responses in PAF patients. Optimized voxel-based morphometry of structural magnetic resonance scans was used to test for regional differences in grey and white matter in 15 PAF patients and matched controls. There were no group differences observed in global measures of grey matter, white matter, or cerebrospinal fluid (CSF). We identified morphometric differences reflecting regional decreases in grey matter volume and concentration in anterior cingulate and insular cortices in PAF patients relative to controls. Morphometric differences in brainstem and subcortical regions did not reach statistical significance. Our findings suggest that peripheral autonomic denervation is associated with grey matter loss in cortical regions encompassing areas that we have previously shown are functionally involved in generation and representation of bodily states of autonomic arousal. The nature of these changes cannot be determined from morphometric analysis alone, but we suggest that they reflect experience-dependent change consequent upon loss of afferent input to brain regions involved in representation of autonomic states.
Mots-clé
Adult, Aged, Autonomic Nervous System Diseases/diagnosis, Autonomic Nervous System Diseases/pathology, Brain/pathology, Brain/physiology, Brain Mapping, Cerebrospinal Fluid, Dominance, Cerebral/physiology, Female, Gyrus Cinguli/pathology, Humans, Image Processing, Computer-Assisted, Magnetic Resonance Imaging/statistics & numerical data, Male, Middle Aged, Reference Values, Reproducibility of Results
Pubmed
Web of science
Création de la notice
11/09/2011 21:57
Dernière modification de la notice
20/08/2019 14:21
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