Les deux visages de l'autophagie dans le système nerveux [The two faces of autophagy in the nervous system].

Détails

ID Serval
serval:BIB_348F8EDB726F
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Les deux visages de l'autophagie dans le système nerveux [The two faces of autophagy in the nervous system].
Périodique
Médecine Sciences
Auteur(s)
Puyal J., Ginet V., Vaslin A., Truttmann A.C., Clarke P.G.
ISSN
0767-0974 (Print)
ISSN-L
0767-0974
Statut éditorial
Publié
Date de publication
04/2009
Peer-reviewed
Oui
Volume
25
Numéro
4
Pages
383-390
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; Review
Publication Status: ppublish
Résumé
Autophagy is a cellular mechanism for degrading proteins and organelles. It was first described as a physiological process essential for maintaining homeostasis and cell survival, but understanding its role in conditions of stress has been complicated by the recognition of a new type of cell death ("type 2") characterized by deleterious autophagic activity. This paradox is important in the central nervous system where the activation of autophagy seems to be protective in certain neurodegenerative diseases but deleterious in cerebral ischemia. The development of new therapeutic strategies based on the manipulation of autophagy will need to take into account these opposing roles of autophagy.
Mots-clé
Animals, Autophagy/genetics, Autophagy/physiology, Brain Ischemia/pathology, Brain Ischemia/physiopathology, Chick Embryo, Embryonic Development, Humans, Larva/growth & development, Lysosomes/physiology, Mammals/genetics, Mammals/physiology, Models, Biological, Molecular Chaperones/physiology, Multiprotein Complexes/physiology, Nerve Tissue Proteins/genetics, Nerve Tissue Proteins/physiology, Nervous System Physiological Phenomena, Neurodegenerative Diseases/physiopathology, Phosphatidylinositol 3-Kinases/physiology, Protein Kinases/physiology, Ranidae/growth & development, Receptors, N-Methyl-D-Aspartate/agonists, Receptors, N-Methyl-D-Aspartate/physiology, TOR Serine-Threonine Kinases
Pubmed
Web of science
Open Access
Oui
Création de la notice
19/05/2009 9:16
Dernière modification de la notice
20/08/2019 14:21
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