Acquired antibody levels to Plasmodium falciparum merozoite surface antigen 1 in residents of a highly endemic area of Papua New Guinea

Détails

ID Serval
serval:BIB_3487C666D1BB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Acquired antibody levels to Plasmodium falciparum merozoite surface antigen 1 in residents of a highly endemic area of Papua New Guinea
Périodique
Transactions of the Royal Society of Tropical Medicine and Hygiène
Auteur(s)
al-Yaman  F., Genton  B., Kramer  K. J., Taraika  J., Chang  S. P., Hui  G. S., Alpers  M. P.
ISSN
0035-9203 (Print)
Statut éditorial
Publié
Date de publication
10/1995
Volume
89
Numéro
5
Pages
555-9
Notes
Journal Article
Research Support, U.S. Gov't, Non-P.H.S. --- Old month value: Sep-Oct
Résumé
The prevalence and concentration of antibodies to a yeast-expressed N-terminal region (195A) and a baculo-virus-expressed C-terminal region (BVp42) of merozoite surface antigen 1 (MSA-1) were measured during a cross-sectional survey in the Wosera area of East Sepik Province, Papua New Guinea, in order to obtain baseline data on naturally acquired antibody response to this antigen in preparation for a vaccine trial. Overall, the seropositivity rate was 78% for 195A and 91% for BVp42. Although antibody prevalence to both molecules increased with age, higher antibody prevalence rates were observed for BVp42 in all age groups studied. In children, significant positive associations were found between parasite prevalence and antibody prevalence for both regions of MSA-1 and between spleen rates and anti-BVp42 antibody prevalence. Concentration of antibody against both regions increased significantly with age, but was always higher for BVp42. In children, antibody levels to both regions of MSA-1 were significantly higher in those infected (symptomatic and asymptomatic), while in adults no significant difference in antibody concentration was observed between those infected and those uninfected. However, enlarged spleens were associated with higher antibody concentration to both regions of MSA-1 in both children and adults. The C-terminal of MSA-1 appeared to be more recognized than the N-terminal, in terms of both antibody prevalence and concentration.
Mots-clé
Adolescent Adult Age Factors Animals Antibodies, Protozoan/*analysis Antigens, Protozoan/immunology Antigens, Surface/immunology Child Child, Preschool Cross-Sectional Studies Female Humans Immunoglobulin G/analysis Infant Malaria, Falciparum/epidemiology Male Papua New Guinea/epidemiology Plasmodium falciparum/*immunology Prevalence
Pubmed
Web of science
Création de la notice
28/01/2008 11:48
Dernière modification de la notice
20/08/2019 13:21
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