Occurrence of Aspergillus fumigatus azole resistance in soils from Switzerland.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_33FFF4F070B5
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Occurrence of Aspergillus fumigatus azole resistance in soils from Switzerland.
Périodique
Medical mycology
ISSN
1460-2709 (Electronic)
ISSN-L
1369-3786
Statut éditorial
Publié
Date de publication
06/11/2023
Peer-reviewed
Oui
Volume
61
Numéro
11
Pages
myad110
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
Aspergillus fumigatus is a fungal species causing diverse diseases in humans. The use of azoles for treatments of A. fumigatus diseases has resulted in azole resistance. Azoles are also widely used in the environment for crop protection, which resulted in azole resistance. Resistance is primarily due to mutations in cyp51A, which encodes the target protein for azoles. Here we addressed the occurrence of azole resistance in soils from a vast part of Switzerland. We aimed to associate the use of azoles in the environment with the occurrence of azole resistance. We targeted sample sites from different agricultural environments as well as sites with no agricultural practice (natural sites and urban sites). Starting from 327 sites, 113 A. fumigatus isolates were recovered (2019-2021), among which 19 were azole-resistant (15 with TR34/L98H and four with TR46/Y121F/T289A resistance mutations in cyp51A). Our results show that azole resistance was not associated with a specific agricultural practice. Azoles could be chemically detected in investigated soils, however, their presence was not associated with the occurrence of azole-resistant isolates. Interestingly, genetic markers of resistance to other fungicides were detected but only in azole-resistant isolates, thus reinforcing the notion that A. fumigatus cross-resistance to fungicides has an environmental origin. In conclusion, this study reveals the spreading of azole resistance in A. fumigatus from the environment in Switzerland. The proximity of agricultural areas to urban centers may facilitate the transmission of resistant strains to at-risk populations. Thus, vigilant surveillance is required to maintain effective treatment options for aspergillosis.
Mots-clé
Humans, Aspergillus fumigatus, Azoles/pharmacology, Fungicides, Industrial, Antifungal Agents/pharmacology, Antifungal Agents/therapeutic use, Soil, Switzerland, Fungal Proteins/genetics, Drug Resistance, Fungal/genetics, Microbial Sensitivity Tests/veterinary, Aspergillus, azoles, fungicides, resistance
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/11/2023 14:21
Dernière modification de la notice
09/02/2024 9:44