Expanding the therapeutic index of radiation therapy by normal tissue protection.

Détails

ID Serval
serval:BIB_33F51A1C2CCF
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Expanding the therapeutic index of radiation therapy by normal tissue protection.
Périodique
The British journal of radiology
Auteur(s)
Montay-Gruel P., Meziani L., Yakkala C., Vozenin M.C.
ISSN
1748-880X (Electronic)
ISSN-L
0007-1285
Statut éditorial
Publié
Date de publication
01/2019
Peer-reviewed
Oui
Volume
92
Numéro
1093
Pages
20180008
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Normal tissue damages induced by radiation therapy remain dose-limiting factors in radiation oncology and this is still true despite recent advances in treatment planning and delivery of image-guided radiation therapy. Additionally, as the number of long-term cancer survivors increases, unacceptable complications emerge and dramatically reduce the patients' quality of life. This means that patients and clinicians expect discovery of new options for the therapeutic management of radiation-induced complications. Over the past four decades, research has enhanced our understanding of the pathophysiological, cellular and molecular processes governing normal tissue toxicity. Those processes are complex and involve the cross-talk between the various cells of a tissue, including fibroblasts, endothelial, immune and epithelial cells as well as soluble paracrine factors including growth factors and proteases. We will review the translatable pharmacological approaches that have been developed to prevent, mitigate, or reverse radiation injuries based upon the targeting of cellular and signalling pathways. We will summarize the different steps of the research strategy, from the definition of initial biological hypotheses to preclinical studies and clinical translation. We will also see how novel research and therapeutic hypotheses emerge along the way as well as briefly highlight innovative approaches based upon novel radiotherapy delivery procedures.
Mots-clé
Animals, Cell Death/radiation effects, Dose-Response Relationship, Radiation, Humans, Neoplasms/pathology, Neoplasms/radiotherapy, Oxidation-Reduction/drug effects, Patient Safety, Proton Therapy/adverse effects, Proton Therapy/methods, Radiation Injuries/prevention & control, Radiotherapy/adverse effects, Radiotherapy/methods, Radiotherapy, Image-Guided/methods, Reference Values
Pubmed
Web of science
Création de la notice
26/04/2018 16:36
Dernière modification de la notice
26/06/2020 5:21
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