Splice junctions follow a 205-base ladder

Détails

ID Serval
serval:BIB_33E4F0F67986
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Splice junctions follow a 205-base ladder
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Beckmann  J. S., Trifonov  E. N.
ISSN
0027-8424 (Print)
Statut éditorial
Publié
Date de publication
03/1991
Volume
88
Numéro
6
Pages
2380-3
Notes
Journal Article --- Old month value: Mar 15
Résumé
Of all aspects of mRNA maturation the accuracy of intervening sequence excision and exon ligation is, perhaps, the most enigmatic. Attempts to identify the essential elements involved in this process have thus far not yielded any satisfactory answer as to what structural (sequence) features are prerequisite for the vital precision of this process. In our search for underlying structural orders we asked whether exons and introns had any positional preferences within a gene. This analysis led to the unexpected discovery that the DNA length is synchronized between successive 3' splicing sites as well as between successive 5' splicing sites, with a frame of approximately 205 base pairs. This observation reveals additional organization of genes in eukaryotes and, perhaps, links gene splicing with chromatin structure.
Mots-clé
Animals *Base Sequence DNA/genetics Evolution *Exons Humans *Introns Mice *RNA Splicing RNA, Messenger/*genetics
Pubmed
Web of science
Open Access
Oui
Création de la notice
25/01/2008 17:18
Dernière modification de la notice
20/08/2019 14:20
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