Imaging of inflammatory and infectious lesions after injection of radioiodinated monoclonal anti-granulocytes antibodies.

Détails

ID Serval
serval:BIB_33A6DCBF557B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Imaging of inflammatory and infectious lesions after injection of radioiodinated monoclonal anti-granulocytes antibodies.
Périodique
Nuclear Medicine Communications
Auteur⸱e⸱s
Locher J.T., Seybold K., Andres R.Y., Schubiger P.A., Mach J.P., Buchegger F.
ISSN
0143-3636 (Print)
ISSN-L
0143-3636
Statut éditorial
Publié
Date de publication
1986
Peer-reviewed
Oui
Volume
7
Numéro
9
Pages
659-670
Langue
anglais
Résumé
Successful detection of inflammatory lesions by planar scintigraphy and SPECT after injection of iodine-123 labelled monoclonal antibodies directed against human granulocytes (123I-Mabgc) is demonstrated. This new tracer has been compared with indium-111 labelled white blood cells (111In-WBC) in selected patients with proven infectious lesions. Scans were equally positive in all cases, but the methodical advantages of the new marker were obvious, namely, there is no need for cell separation and the images of inflammatory lesions were better defined. In addition, SPECT could be performed with 123I-Mabgc and allowed a better anatomic localization and a three-dimensional description of the lesions. No adverse reactions have been seen. It is concluded, therefore, that 123I-Mabgc is a promising agent for the detection of acute focal inflammatory lesions which may, with advantages, replace 111In-WBC.
Mots-clé
Antibodies, Monoclonal/diagnostic use, Arthritis, Infectious/radionuclide imaging, Bacterial Infections/radionuclide imaging, Colitis/radionuclide imaging, Drug Evaluation, Glycoproteins/immunology, Granulocytes/immunology, Humans, Indium/diagnostic use, Iodine Radioisotopes/diagnostic use, Osteomyelitis/radionuclide imaging, Radioisotopes/diagnostic use, Tomography, Emission-Computed
Pubmed
Web of science
Création de la notice
25/01/2008 11:28
Dernière modification de la notice
20/08/2019 13:19
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