Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery.
Détails
ID Serval
serval:BIB_338C8092DC5C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Evaluating the incidence of pathological complete response in current international rectal cancer practice: the barriers to widespread safe deferral of surgery.
Périodique
Colorectal disease
Collaborateur⸱rice⸱s
2017 European Society of Coloproctology (ESCP) collaborating group
Contributeur⸱rice⸱s
Glasbey J.C., Neary P., Negoi I., Kamarajah S., Sgro A., Bhangu A., Pinkney T., Frasson M., El-Hussuna A., Battersby N.J., Bhangu A., Buchs N.C., Buskens C., Chaudri S., Gallo G., Glasbey J., Minaya-Bravo A.M., Morton D., Nepogodiev D., Pata F., Sánchez-Guillén L., Singh B., Zmora O., Perry R., Magill L., Bhangu A., Altomare D., Bemelman W., Brown S., Denost Q., Knowles C., Laurberg S., Lefevre J.H., Möeslein G., Pinkney T., Vaizey C., Bilali S., Bilali V., Salomon M., Cillo M., Estefania D., Patron Uriburu J., Ruiz H., Farina P., Carballo F., Guckenheimer S., Proud D., Brouwer R., Bui A., Nguyen B., Smart P., Warwick A., Theodore J.E., Herbst F., Birsan T., Dauser B., Ghaffari S., Hartig N., Stift A., Argeny S., Unger L., Strouhal R., Heuberger A., Varabei A., Lahodzich N., Makhmudov A., Selniahina L., Feryn T., Leupe T., Maes L., Reynvoet E., Van Langenhove K., Nachtergaele M., Monami B., Francart D., Jehaes C., Markiewicz S., Weerts J., Van Belle K., Bomans B., Cavenaile V., Nijs Y., Vertruyen M., Pletinckx P., Claeys D., Defoort B., Muysoms F., Van Cleven S., Lange C., Vindevoghel K., Wolthuis A., Todorovic M., Dabic S., Kenjic B., Lovric S., Vidovic J., Delibegovic S., Mehmedovic Z., Christiano A., Lombardi B., Marchiori M., Tercioti V., Dardanov D., Petkov P., Simonova L., Yonkov A., Zhivkov E., Maslyankov S., Pavlov V., Sokolov M., Todorov G., Stoyanov V., Batashki I., Iarumov N., Lozev I., Moshev B., Slavchev M., Atanasov B., Belev N., Krstev P., Penkov R., Šantak G., Ćosić J., Previšić A., Vukušić L., Zukanović G., Zelić M., Kršul D., Lekić Vitlov V., Mendrila D., Orhalmi J., Dusek T., Maly O., Paral J., Sotona O., Skrovina M., Bencurik V., Machackova M., Kala Z., Farkašová M., Grolich T., Procházka V., Hoch J., Kocian P., Martinek L., Antos F., Pruchova V., El-Hussuna A., Ceccotti A., Madsbøll T., Straarup D., Uth Ovesen A., Christensen P., Bondeven P., Edling P., Elfeki H., Alexandrovich Gameza V., Michelsen Bach S., Zheltiakova I., Krarup P.M., Krogh A., Rolff H.C., Lykke J., Juvik A.F., Lóven HHK, Marckmann M., Osterkamp JTF, Madsen A.H., Worsøe J., Ugianskis A., Kjaer M.D., Youn Cho Lee B., Khalid A., Kristensen M.H., El Sorogy M., Elgeidie A., Elhemaly M., El Nakeeb A., Elrefai M., Shalaby M., Emile S., Omar W., Sakr A., Thabet W., Awny S., Metwally I., Refky B., Shams N., Zuhdy M., Lepistö A., Keränen I., Kivelä A., Lehtonen T., Siironen P., Rautio T., Ahonen-Siirtola M., Klintrup K., Paarnio K., Takala H., Hyöty M., Haukijärvi E., Kotaluoto S.M., Lehto K., Tomminen T., Huhtinen H., Carpelan A., Karvonen J., Rantala A., Varpe P., Cotte E., Francois Y., Glehen O., Passot G., d'Alessandro A., Chouillard E., Etienne J.C., Ghilles E., Vinson-Bonnet B., Germain A., Ayav A., Bresler L., Chevalier R., Denost Q., Didailler R., Rullier E., Tiret E., Chafai N., Lefevre J.H., Parc Y., Sielezneff I., Mege D., Lakkis Z., Barussaud M., Krones C., Bock B., Webler R., Baral J., Lang T., Münch S., Pullig F., Schön M., Hinz S., Becker T., Möller T., Richter F., Schafmayer C., Hardt J., Kienle P., Crescenti F., Ahmad M., Soleiman Y., Papaconstantinou I., Gklavas A., Nastos K., Theodosopoulos T., Vezakis A., Stamou K., Saridaki A., Xynos E., Paraskakis S., Zervakis N., Skroubis G., Amanatidis T., Germanos S., Maroulis I., Papadopoulos G., Dimitriou N., Alexandrou A., Felekouras E., Griniatsos J., Karavokyros I., Papadopoulos A., Chouliaras C., Ioannidis P., Katsounis D., Kefalou E., Katsoulis I.E., Balalis D., Korkolis D.P., Manatakis D., Tzovaras G., Baloyiannis I., Mamaloudis I., Lázár G., Ábraham S., Paszt A., Simonka Z., Tóth I., Zaránd A., Baranyai Z., Ferreira G., Harsányi L., Ónody P., Banky B., Burány Á., Lakatos M., Marton J., Solymosi A., Besznyák I., Bursics A., Papp G., Saftics G., Svastics I., Valsdottir E., Atladottir J., Jonsson T., Moller P., Sigurdsson H., Gupta S.K., Gupta S., Kaul N., Mohan S., Sharma G., Wani R., Chowdri N., Khan M., Mehraj A., Parray F.Q., Coveney A., Burke J., Deasy J., El-Masry S., McNamara D., Khan M.F., Cahill R., Faul E., Mulsow J., Shields C., Kelly M.E., Bass G., Martin S.T., O'Connell R., Ryan E., Connelly T., Ahmad G., Bukhari W., Cooke F., Zmora O., Gold Deutch R., Haim N., Lavy R., Moscovici A., Shussman N., Gefen R., Marom G., Pikarsky A., Weiss D., Avital S., Hermann N., Raguan B., Slavin M., White I., Wasserberg N., Arieli H., Gurevich N., Freund M.R., Dorot S., Edden Y., Halfteck G., Reissman P., Pery R., Tulchinsky H., Weizman A., Agresta F., Curinga R., Finotti E., Savino G., Verza L.A., Asteria C.R., Boccia L., Pascariello A., Tamini N., Bugatti A., Gianotti L., Totis M., Vincenti L., Andriola V., Giannini I., Travaglio E., Balestri R., Buccianti P., Roffi N., Rossi E., Urbani L., Mellano A., Cinquegrana A., Lauretta A., Belluco C., Mistrangelo M., Allaix M.E., Arolfo S., Morino M., Testa V., Delrio P., Pace U., Rega D., Scala D., Gallo G., Clerico G., Cornaglia S., Realis Luc A., Trompetto M., Ugolini G., Antonacci N., Fabbri S., Montroni I., Zattoni D., D'Urbano C., Cornelli A., Viti M., Inama M., Bacchion M., Casaril A., Impellizzeri H., Moretto G., Spinelli A., Carvello M., David G., Di Candido F., Sacchi M., Frontali A., Ceriani V., Molteni M., Rosati R., Aleotti F., Elmore U., Lemma M., Vignali A., Scabini S., Casoni Pattacini G., Luzzi A., Romairone E., Marino F., Lorusso D., Pezzolla F., Colombo F., Baldi C., Foschi D., Sampietro G., Sorrentino L., Di Saverio S., Birindelli A., Segalini E., Spacca D., Romano G.M., Belli A., Bianco F., De Franciscis S., Falato A., Muratore A., Marsanic P., Grimaldi S., Castaldo N., Ciolli M.G., Picarella P., Porfidia R., Tugnoli G., Bondurri A., Cavallo D., Maffioli A., Pertusati A., Pulighe F., Balestra F., De Nisco C., Podda M., Opocher E., Longhi M., Mariani N.M., Maroni N., Pisani Ceretti A., Galleano R., Aonzo P., Curletti G., Reggiani L., Marconi M., Del Prete L., Oldani M., Pappalardo R., Zaccone L S., Scatizzi M., Baraghini M., Cantafio S., Feroci F., Giani I., Tutino R., Cocorullo G., Gulotta G., Licari L., Salamone G., Sileri P., Saraceno F., La Torre F., Chirletti P., Coletta D., De Toma G., Mingoli A., Papandrea M., De Luca E., Sacco R., Sammarco G., Vescio G., Tonini V., Bianchini S., Cervellera M., Vaccari S., Cracco N., Barugola G., Bertocchi E., Rossini R., Ruffo G., Sartori A., Clemente N., De Luca M., De Luca A., Scaffidi G., Lorenzon L., Balducci G., Bocchetti T., Ferri M., Mercantini P., Pata F., Bauce S., Benevento A., Bottini C., Crapa P.R., Rubbini M., Anania G., Carcoforo P., Cavallesco G., Feo C., Yamamoto T., Sivins A., Ancans G., Gerkis S., Lunis R., Pcolkins A., Venskutonis D., Bradulskis S., Dainius E., Subocius A., Vencius J., Zeromskas P., Eismontas V., Nutautiene V., Simcikas D., Tamosiunas A., Svagzdys S., Latkauskas T., Lizdenis P., Saladzinskas Z., Tamelis A., Dulskas A., Kuliavas J., Samalavicius N.E., Poskus T., Jotautas V., Mikalauskas S., Poskus E., Strupas K., Zakaria A.D., Lah N.N., Wong M., Zain W.Z., Zakaria Z., Mazlan L., Mohd Azman Z.A., Sagap I., Psaila J., Andrejevic P., Cini C., Ellul S., Pace K., Ahallat M., Hamid M., Hrora A., Majbar M.A., Raiss M., Westerduin E., Bemelman W., Buskens C., Tanis P., van der Sluis P.C., Davids P.H., Pronk A., Schiphorst AHW, Smakman N., Zimmerman D., Koeter T., Stijns J., van Loon Y.T., Vermaas M., de Graaf E., Doornebosch P., van Hagen P., van Ruler O., Toorenvliet B., Nonner J., van den Berg I., van Steensel L., Vles W., Melenhorst J., Orsini R., Visschers R., Hoff C., Blom R., Marsman H., Mulder I., Cense H., de Castro S., Demirkiran A., Hunfeld M., van Geloven A., de Groof J., Hendriks E., Leeuwenburg M., van Oorschot N., Wit F., Rupert C., Veldman P., Keijzers M., Konsten J., Den Boer F., Corver M., Boerma E.G., Koolen L., Martens M., Van Wijck K., Ignjatovic D., Breuer R., Gurpreet B., Oresland T., Tetens Moe T., Nesbakken A., Flaaten Backe I., Wik T.A., Radiya K., Dehli T., Gjessing P., Norderval S., Woll K., Anwer M., Qureshi M.S., Qureshi A.U., Billah M., Jawad M.Y., Raza A., Urooj N., Wang X., Li L., Jajtner D., Gasinski B., Kabiesz W., Walega P., Romaniszyn M., Zawadzki M., Czarnecki R., Obuszko Z., Rzaca M., Sitarska M., Silva P., Duarte A., Gonçalves D., Morais M., Rama N., Nobre J., Sales I., Costa Pereira J., Costa S., Costa Pereira C., Insua C., Romero I., Figueiredo N., Cunha J., Domingos H., Vieira P., Cunha M., Americano M., Amorim E., Rachadell J., Carvas J.M., Armas I., Fernandes P., Pires C., Reis R., Martins R., Dos Santos M., Henriques P., Oliveira O., Duarte M., Ferreira L., Miranda J., Vilela N., Corte Real J., Carlos S., Frois Borges M., Moniz Pereira P., Simões J., Silva-Vaz P., Bettencourt V., Gouveia A., Perez H., Rainho R., Bintintan V., Ciuce C., Dindelegan G., Scurtu R., Seicean R., Cristian D., Burcos T., Grama F., Mandi D.M., Richiteanu G., Miron A., Calu V., Enciu O., Nadragea M., Parvuletu R., Mogoanta S.S., Crafciuc A., Paitici S., Negoi I., Beuran M., Ciubotaru C., Prodan A., Vartic M., Tomulescu V., Copaescu C., Yanishev A., Abelevich A., Kokobelyan A., Lebedeva M., Luzan R., Pozdnyakov A., Cherdancev D., Mahotin D., Nesytykh A., Samsonyuk V., Pravosudov I., Ivlev D., Karachun A., Lebedev K., Samsonov D., Aiupov R., Feoktistov D., Garipov M., Suleymanov N., Tarasov N., Rasulov A., Dzhumabaev H., Mamedli Z., Bedzhanyan A., Popov D., Sednev A., Klimenko A., Semenov A., Vasilyev S., Khazov A., Khanevich M., Khrykov G., Katorkin S., Andreev P., Chernov A., Davidova O., Zhuravlev A., Achkasov S., Shakhmatov D., Shelygin Y., Sushkov O., Vardanyan A., Ilkanich A., Barbashinov N., Darvin V., Onishchenko S., Voronin Y., Krivokapić Z., Barišić G., Dimitrijević I., Marković V., Sekulić A., Stanojevic G., Brankovic B., Nestorovic M., Pecic V., Petrovic D., Kostic I., Aleksic A., Dabic D., Maric B., Perunicic V., Radovanovic Z., Djuric M., Lukic D., Radovanovic D., Cuk V., Juloski J., Kenic M., Krdzic I., Ngu J.C., Ng Y.Y., Teo N., Korcek J., Lazorisak A., Rems M., Ramovš Trampuš Š., Tomazic A., Grosek J., Kosir J., Norcic G., Vigorita V., Caceres N., Casal E., Ruano A., Trostchansky I., Golda T., Galvez Saldaña A., Kreisler Moreno E., Lopez Dominguez J., Vila Tura M., Labarga F., Galvez P., Maderuelo V., Suero C., Bargallo J., Cayetano L., Lamas S., Silva M.C., Bernal-Sprekelsen J.C., Gómez R., Jareño S., Ríos A., Vercher D., García-González J.M., Cervera-Aldama J., Ramos-Prada J., Santamaría-Olabarrieta M., Borda N., Enrriquez-Navascués J.M., Saralegui Y., Calero-Lillo A., Aznar-Puig S., López-Lara M.A., Muñoz-Collado S., Valverde-Sintas J., Menendez P., Leon C., Truan N., Baldonedo R., Fernández-Martínez D., Otero J., Solar-García L., Turrado-Rodriguez V., de Lacy Oliver F., Lacy Fortuny A.M., Martin Perez B., Otero Piñeiro A.M., Paredes J., Fernandez F., Ladra M.J., Paulos A., Prieto D., Beltrán de Heredia J.P., Blanco Antona F., de Andrés Asenjo B., Ferreras García C., Romero de Diego A., Cordoba Diaz de Laspra E., Echazarreta Gallego E., Elia Guedea M., Escola D., Martinez S., Primo Romaguera V., Parreño R., Pastor L., Rosell E., Lozoya Trujillo R., Alós Company R., Ruiz Carmona M.D., Solana Bueno A., Salvans Ruiz S., Alonso Gonçalves S., Jiménez-Toscano M., Pascual Damieta M., Pera Roman M., Pellicer-Franco E.M., Garcia-Marin J.A., Mengual-Ballester M., Soria-Aledo V., Valero-Navarro G., Vicente-Ruiz M., Garcia-Zamora C., Gonzalez-Gil A., Montoya-Tabares M.J., Paredes-Quiles M., Die Trill J., Abadia P., Moreno I., Pina J.D., Ramos Rubio D., Escartin J., Blas J.L., Fernando J., Ferrer R., Garcia Egea J., Pros I., Martinez W., Rius J., Socías M., Sabia D., Castellvi Valls J., Gonzalez Santin V., Mompart Garcia S., Viso Pons L., Julià D., Codina-Cazador A., Farrés R., Gómez N., Planellas P., Cuadrado M., Camps I., Rufas M., Escoll J., Fermiñán A., Muriel P., Sierra E., Alvarez-Laso C., Lora P., Padin H., Garcia-Septiem J., Bustamante C., Jimenez V., Jimenez-Miramon J., Ramos J.L., Gallardo A.B., Benito P., Colao L., Galindo P., Garcia C., Forero-Torres A., Alonso Poza A., Dieguez Fernandez B., Gilsanz Martin C., Hernandez Garcia M., Rojo López J.A., Gil López J.M., González Zunzárren M., Martínez Alegre J., Zorrilla Matilla L.P., Navarro-Sánchez A., Alcalá Serrano F.J., López-Fernández J., Montesdeoca Cabrera D., Alvarez-Gallego M., Guevara J., Pascual Miguelañez I., Rubio-Perez I., Gomez Ruiz M., Alonso Martín J., Cagigas Fernández C., Castillo Diego J., Pando J.A., Maristany C., Muñoz-Duyos A., Rada-Palomino A., Vargas-Pierola H., Peña Ros E., Benavides Buleje J.A., Muñoz Camarena J.M., Parra Baños P.A., Ramirez Faraco M., Arenal J.J., Citores M.A., Marcos J.L., Sánchez J., Tinoco C., García Flórez L.J., Arias Pacheco R.D., Mínguez Ruiz G., Gutiérrez Corral N., Rodríguez Infante A., Carrillo López M.J., Carrasco Prats M.M., Lage Laredo A., Martínez Manzano Á., Rodríguez García P., Segura-Sampedro J.J., Alonso-Hernández N., Fernandez Isart M., Gamundi Cuesta M., Ochogavia Segui A., Ibañez N., Abrisqueta J., Lujan J., Gómez Pérez R., Corrales Valero E., Monje Salazar C., Sanchiz Cardenas E., Soler Humanes R., Jimenez-Rodriguez R.M., De la Portilla F., Diaz Pavon J.M., Garcia Cabrera A.M., Reyes Diaz M.L., Espin E., Marinello F., Martí M., Sanchez J.L., Vallribera F., Orts Mico F.J., Ortin Navarro M., Perez Climent M., Serra Diaz C., Millan M., Caro A., Escuder J., Espina B., Feliu F., Climent Aira A., Estévez Diz A., Moreno Asencio M.T., Varela Mato A., Vázquez Bouzán R., Minaya-Bravo A.M., Diez-Alonso M.M., Villeta-Plaza R., Guadalajara H., Alías D., García Olmo D., Pastor C., Valverde I., Sanchez Romero A., Gardea A., Gil Santos M., Nimmersgern T., Serrano Paz P., Romero-Simó M., Blasco-Segura T., Caravaca-García I., Costa-Navarro D., Zarco-Pleguezuelos A., Sánchez-Guillén L., Flor-Lorente B., Frasson M., García-Granero Á., García-Granero E., Arencibia B., Alonso J., Febles G., Nogués E.M., Roque C., Segelman J., Nygren J., Nestler G., Abraham-Nordling M., Egenvall M., Myrelid P., Jung B., Loftås P., Lydrup M.L., Azahr N., Buchwald P., Mangell P., Syk I., Nikberg M., Carlander J., Chabok A., Smedh K., Tiselius C., Haapaniemi S., Benckert A., Adamina M., Freil-Lanter C., Gingert C., Müller P., Schäfli J., Regusci L., Brenna M., Fasolini F., Misteli H., Kirchhoff P., Oertli D., Hahnloser D., Clerc D., Hübner M., Ris F., Buchs N.C., Chevallay M., Morel P., Schiltz B., Wang J.Y., Su W.C., Huang C.W., Ma C.J., Tsai H.L., Bugra D., Agalar F., Baloglu H., Basoglu I., Okkabaz N., Binboga E., Biricik A., Celik A., Yavuz E., Canda A.E., Agalar C., Fuzun M., Sokmen S., Terzi C., Isik A., Karip B., Bilgili A.C., Leventoğlu S., Aytac B., Küçükdiler E., Yıldız A., Yuksel O., Sinan H., Hancerliogullari O., Kaymak S., Kozak O., Ozer M.T., Sarici I.S., Akca O., Kalayci M.U., Kara Y., Agcaoglu O., Balik E., Bayram O., Özbalcı G.S., Özkan B.B., Karabacak U., Sungurtekin U., Ozgen U., Demirbas S., Öztürk E., Isik O., Yilmazlar T., Colak E., Karagul S., Kinas V., Fearnhead N., Lord I., Stewart P., Zammit M., Arnold S., Battersby N.J., Broadhurst J., Moran S., Seretis F., Shabbir J., Jones C., Kynaston J., Vimalachandran D., Blower E., McFaul C., McWhirter D., Pilkington J., Wilson T., Chowdhary M., Stubbs B., Abdalkoddus M., Lai C., Thavanesan N., Yao C., Agarwal T., Dindyal S., Hill RMC, Reade S., Slesser A., Paterson H., Balfour A., Boland M., Geraghty A., O'Kelly J., Patel P., Tezas S., Yahia S., Jadhav V., Marimuthu K., Narayanan A., Piramanayagam B., Bradley N., Buchanan F., Paul K., Singh J., Thomson K., Korsgen S., Bedford M., Lee K., Leong K., McArthur D., Bhangu A., Malik S., Mohamed I., Cunha P., Pilavas A., Reddy A., Ahmed S., Ahmed A., Voll J., Velchuru V., Lal R., Mirshekar-Syahkal B., Kassai M., Aleem M., Keogh-Bootland S., Sarmah P., Brown S., Keegan R., Kelkar A., Sen P., Oliveira-Cunha M., Chaudhri S., Fares R., Singh B., Thomas W.M., Aslam M.I., Boyle K., Hemingway D., Miller A., Norwood M., Gurjar S., Al-Saeedi M., Anandan L., Sudlow A., Zampitis N., Malik K., 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ISSN
1463-1318 (Electronic)
ISSN-L
1462-8910
Statut éditorial
Publié
Date de publication
09/2018
Peer-reviewed
Oui
Volume
20
Numéro
Suppl 6
Pages
58-68
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
The mainstay of management for locally advanced rectal cancer is chemoradiotherapy followed by surgical resection. Following chemoradiotherapy, a complete response may be detected clinically and radiologically (cCR) prior to surgery or pathologically after surgery (pCR). We aim to report the overall complete pathological response (pCR) rate and the reliability of detecting a cCR by conventional pre-operative imaging.
A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any regression from baseline staging following chemoradiotherapy. The primary endpoint was the pCR rate. The secondary endpoint was agreement between post-treatment MRI restaging (yMRI) and final pathological staging.
Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. The pCR rate was 10.3% (67/649), with a partial response in 35.9% (233/649) patients. Comparison of AJCC stage determined by post-treatment yMRI with final pathology showed understaging in 13% (55/429) and overstaging in 34% (148/429). Agreement between yMRI and final pathology for T-stage, N-stage, or AJCC status were each graded as 'fair' only (n = 429, Kappa 0.25, 0.26 and 0.35 respectively).
The reported pCR rate of 10% highlights the potential for non-operative management in selected cases. The limited strength of agreement between basic conventional post-chemoradiotherapy imaging assessment techniques and pathology suggest alternative markers of response should be considered, in the context of controlled clinical trials.
A pre-planned analysis of the European Society of Coloproctology (ESCP) 2017 audit was performed. Patients treated by elective rectal resection were included. A pCR was defined as a ypT0 N0 EMVI negative primary tumour; a partial response represented any regression from baseline staging following chemoradiotherapy. The primary endpoint was the pCR rate. The secondary endpoint was agreement between post-treatment MRI restaging (yMRI) and final pathological staging.
Of 2572 patients undergoing rectal cancer surgery in 277 participating centres across 44 countries, 673 (26.2%) underwent chemoradiotherapy and surgery. The pCR rate was 10.3% (67/649), with a partial response in 35.9% (233/649) patients. Comparison of AJCC stage determined by post-treatment yMRI with final pathology showed understaging in 13% (55/429) and overstaging in 34% (148/429). Agreement between yMRI and final pathology for T-stage, N-stage, or AJCC status were each graded as 'fair' only (n = 429, Kappa 0.25, 0.26 and 0.35 respectively).
The reported pCR rate of 10% highlights the potential for non-operative management in selected cases. The limited strength of agreement between basic conventional post-chemoradiotherapy imaging assessment techniques and pathology suggest alternative markers of response should be considered, in the context of controlled clinical trials.
Mots-clé
Adult, Aged, Chemoradiotherapy, Adjuvant, Europe, Female, Humans, Incidence, Magnetic Resonance Imaging, Male, Medical Audit, Middle Aged, Neoadjuvant Therapy, Neoplasm Staging/methods, Preoperative Period, Prospective Studies, Rectal Neoplasms/diagnostic imaging, Rectal Neoplasms/pathology, Rectal Neoplasms/therapy, Remission Induction, Reproducibility of Results, Response Evaluation Criteria in Solid Tumors, Treatment Outcome, Rectal surgery, deferral of surgery, neoadjuvant therapy, pathology, radiology, rectal cancer, surgical oncology
Pubmed
Web of science
Open Access
Oui
Création de la notice
26/09/2023 13:50
Dernière modification de la notice
27/09/2023 5:59