Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas

Détails

ID Serval
serval:BIB_335DCDEB52A2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Dedifferentiated liposarcomas with divergent myosarcomatous differentiation developed in the internal trunk: a study of 27 cases and comparison to conventional dedifferentiated liposarcomas and leiomyosarcomas
Périodique
American Journal of Surgical Pathology
Auteur⸱e⸱s
Binh  M. B., Guillou  L., Hostein  I., Chateau  M. C., Collin  F., Aurias  A., Binh  B. N., Stoeckle  E., Coindre  J. M.
ISSN
0147-5185
Statut éditorial
Publié
Date de publication
2007
Peer-reviewed
Oui
Volume
31
Numéro
10
Pages
1557-1566
Notes
PT - Journal Article PT - Research Support, Non-U.S. Gov't
Résumé
Dedifferentiated liposarcoma (DLPS) is one of the most frequent sarcomas of the retroperitoneum and represents most undifferentiated sarcomas of the internal trunk. In about 5% cases, the dedifferentiated component is an heterologous sarcoma such as leiomyosarcoma or rhabdomyosarcoma. We reviewed a series of 65 sarcomas with a myogenic differentiation developed in the internal trunk for which initial diagnoses were leiomyosarcoma (37), rhabdomyosarcoma (6), malignant mesenchymoma (6), and DLPS (16). Immunostainings for MDM2, CDK4, alpha smooth actin, desmin, caldesmon, myogenin, c-kit, and progesterone receptor were performed. In 48 cases, the amplification status of MDM2 and CDK4 could be evaluated with quantitative polymerase chain reaction on paraffin-embedded tissues extracted DNAs. After review of the cases, final diagnoses were leiomyosarcoma (35), rhabdomyosarcomatous (20) or leiomyosarcomatous (7) DLPS, probable DLPS (2), and malignant mesenchymoma (1). DLPS were bigger tumors (median: 18.2 cm) than leiomyosarcomas (median: 12 cm). They had a lower 5-year recurrence-free survival than leiomyosarcomas (45% vs. 71%) but a higher 5-year metastasis-free survival (73% vs. 39%). There was no significant difference in overall survival (57% vs. 34%). Outcome of patients with a DLPS with a myosarcomatous component did not differ from conventional DLPS. In conclusion, most sarcomas with a rhabdomyosarcomatous differentiation occurring in the internal trunk of adults are DLPS. Moreover, DLPS with a myogenic component have a low metastatic potential, similar to conventional DLPS and significantly lower to the metastatic potential of leiomyosarcomas
Mots-clé
Adult/Aged/Aged,80 and over/analysis/chemistry/Cyclin-Dependent Kinase 4/DNA,Neoplasm/Female/genetics/Humans/Immunoenzyme Techniques/Leiomyosarcoma/Liposarcoma/Male/metabolism/Middle Aged/mortality/Nucleic Acid Amplification Techniques/Pathology/Proto-Oncogene Proteins c-mdm2/Retroperitoneal Neoplasms/Rhabdomyosarcoma/Soft Tissue Neoplasms/Tumor Markers,Biological
Pubmed
Web of science
Création de la notice
29/01/2008 18:34
Dernière modification de la notice
20/08/2019 13:19
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