Overlapping, additive and counterregulatory effects of type II and I interferons on myeloid dendritic cell functions.

Détails

Ressource 1Télécharger: 22125457_BIB_334EB6C2E996.pdf (906.76 [Ko])
Etat: Public
Version: Final published version
Licence: Non spécifiée
ID Serval
serval:BIB_334EB6C2E996
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Overlapping, additive and counterregulatory effects of type II and I interferons on myeloid dendritic cell functions.
Périodique
Thescientificworldjournal
Auteur⸱e⸱s
Frasca L., Lande R.
ISSN
1537-744X (Electronic)
ISSN-L
1537-744X
Statut éditorial
Publié
Date de publication
2011
Volume
11
Pages
2071-2090
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
Dendritic cells (DCs) are central player in immunity by bridging the innate and adaptive arms of the immune system (IS). Interferons (IFNs) are one of the most important factors that regulate both innate and adaptive immunity too. Thus, the understanding of how type II and I IFNs modulate the immune-regulatory properties of DCs is a central issue in immunology. In this paper, we will address this point in the light of the most recent literature, also highlighting the controversial data reported in the field. According to the wide literature available, type II as well as type I IFNs appear, at the same time, to collaborate, to induce additive effects or overlapping functions, as well as to counterregulate each one's effects on DC biology and, in general, the immune response. The knowledge of these effects has important therapeutic implications in the treatment of infectious/autoimmune diseases and cancer and indicates strategies for using IFNs as vaccine adjuvants and in DC-based immune therapeutic approaches.
Pubmed
Web of science
Open Access
Oui
Création de la notice
23/03/2012 11:20
Dernière modification de la notice
20/08/2019 13:19
Données d'usage