Recurrence rate after discontinuation of long-term mebendazole therapy in alveolar echinococcosis (preliminary results)
Détails
ID Serval
serval:BIB_332525DEBA3D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Recurrence rate after discontinuation of long-term mebendazole therapy in alveolar echinococcosis (preliminary results)
Périodique
American Journal of Tropical Medicine and Hygiène
ISSN
0002-9637 (Print)
Statut éditorial
Publié
Date de publication
11/1990
Volume
43
Numéro
5
Pages
506-15
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Nov
Research Support, Non-U.S. Gov't --- Old month value: Nov
Résumé
The recurrence rate was investigated in 19 patients with non-resectable alveolar echinococcosis after discontinuation of a long-term therapy with mebendazole (average treatment 4.3 years). A control group consisted of 14 patients who underwent radical surgery and finished a course of prophylactic postoperative mebendazole treatment of 2 years. In the controls, no recurrence was observed after a post-therapy period averaging 3.5 years. In contrast, recurrence occurred in 7/19 patients (37%) with non-resectable alveolar echinococcosis an average of 1.6 years after discontinuation of the long-term mebendazole therapy. The absence of clinically detectable recurrence in the remaining 12 patients seems to be due either to spontaneous inactivation of alveolar echinococcosis preceding chemotherapy or too short post-therapy surveillance. The patients with recurrence responded favorably to reintroduction of chemotherapy. The data indicate that mebendazole therapy is parasitostatic rather than parasiticidal.
Mots-clé
Adult
Aged
Echinococcosis, Hepatic/*drug therapy/surgery
Female
Humans
Liver/parasitology
Male
Mebendazole/administration & dosage/*therapeutic use
Middle Aged
Recurrence
Pubmed
Web of science
Création de la notice
24/01/2008 17:41
Dernière modification de la notice
20/08/2019 14:19