Comparison of 5-tiered and 6-tiered diagnostic systems for the reporting of thyroid cytopathology: a multi-institutional study.

Détails

ID Serval
serval:BIB_32FFA4EBDCAD
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Comparison of 5-tiered and 6-tiered diagnostic systems for the reporting of thyroid cytopathology: a multi-institutional study.
Périodique
Cancer Cytopathology
Auteur(s)
Bongiovanni M., Crippa S., Baloch Z., Piana S., Spitale A., Pagni F., Mazzucchelli L., Di Bella C., Faquin W.
ISSN
1934-6638 (Electronic)
ISSN-L
1934-662X
Statut éditorial
Publié
Date de publication
2012
Volume
120
Numéro
2
Pages
117-125
Langue
anglais
Notes
Publication types: Journal Article ; Multicenter Study Publication Status: ppublish
Résumé
BACKGROUND: At present, thyroid fine-needle aspiration (FNA) specimens are diagnosed using a tiered classification scheme, with the most popular of these being the 5-tiered and 6-tiered systems. In this study, the authors present their institutional experiences using these 2 different systems and evaluate their efficacy based on the surgical follow-up.
METHODS: Thyroid FNA specimens and their corresponding surgical resection specimens were collected between 2007 and 2009. The following diagnostic categories are used in both systems: unsatisfactory/nondiagnostic, benign, follicular neoplasm/suspicious for follicular neoplasm, suspicious for malignancy, and malignant. An additional category termed atypia of undetermined significance/follicular lesion of undetermined significance was used for atypical cases in the 6-tiered system. Statistical analysis was performed by comparing the different diagnostic categories.
RESULTS: The case cohort included a total of 7686 thyroid FNA specimens representing 3962 nodules and 3724 nodules, respectively, in the 5-tiered and 6-tiered systems. Negative predictive values for the benign categories (96.9% vs 97.5%; P = 1) and positive predictive values for both the follicular neoplasm categories (26.5% vs 32.1%; P = .2531) and the malignant categories (99.1% vs 99.4%; P = 1) were similar. The most significant differences between the 5-tiered and 6-tiered systems were the percentage of cases classified as benign (83.9% vs 55.4%; P < .0001) and as follicular neoplasms (4.6% vs 23.8%; P < .0001). It is interesting to note that fewer patients were referred for surgery in the 5-tiered system compared with the 6-tiered one (9.1% vs 36.5%; P < .0001).
CONCLUSIONS: Use of either the 5-tiered or 6-tiered reporting systems for thyroid FNA specimens can potentially affect the clinical management of patients with thyroid nodules.
Mots-clé
Adenocarcinoma, Follicular/pathology, Adenocarcinoma, Follicular/surgery, Adolescent, Adult, Aged, Aged, 80 and over, Biopsy, Fine-Needle, Cohort Studies, Female, Follow-Up Studies, Humans, Male, Middle Aged, Prognosis, Thyroid Gland/pathology, Thyroid Gland/surgery, Thyroid Neoplasms/pathology, Thyroid Neoplasms/surgery, Young Adult
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/02/2015 10:39
Dernière modification de la notice
20/08/2019 13:18
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