Decreased sensitivity to alpha-adrenergic stimulation in hypothyroid patients

Détails

ID Serval
serval:BIB_32F6F705480B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Decreased sensitivity to alpha-adrenergic stimulation in hypothyroid patients
Périodique
Journal of Clinical Endocrinology and Metabolism
Auteur(s)
Polikar  R., Kennedy  B., Ziegler  M., Smith  J., Nicod  P.
ISSN
0021-972X (Print)
Statut éditorial
Publié
Date de publication
06/1990
Volume
70
Numéro
6
Pages
1761-4
Notes
Journal Article
Research Support, U.S. Gov't, P.H.S. --- Old month value: Jun
Résumé
Nine hypothyroid patients had blood pressure and pulse rate responses to the alpha-adrenergic agonist phenylephrine measured before [T4 index, 45.045 +/- 9.009 nmol/L (mean +/- SEM); TSH, 57.1 +/- 23.6 mU/L] and after 4 +/- 0.5 months of thyroid replacement therapy (T4 index, 141.570 +/- 29.601 nmol/L; TSH, 2.6 +/- 1.0 mU/L). Hypothyroid patients had a smaller blood pressure increment and heart rate decrement at both 66.7 and 100 micrograms/min infusion rates of phenylephrine. Furthermore, the slope of the dose-response curves for systolic (2.06 +/- 0.22 vs. 1.32 +/- 0.19; P less than 0.01) and diastolic (1.04 +/- 0.18 vs. 0.62 +/- 0.08; P less than 0.01) blood pressures were significantly greater after thyroid replacement therapy. Pulse rate changes remained proportional to blood pressure changes in hypothyroid patients, so there was no change in baroreflex sensitivity. Plasma norepinephrine levels were higher before than after thyroid replacement (2.41 +/- 0.28 vs. 1.82 +/- 0.29 nmol/L, respectively; P less than 0.01). Thus, hypothyroid patients have diminished pressor sensitivity to an alpha-adrenergic agonist and increased plasma levels of the alpha-adrenergic neutrotransmitter norepinephrine.
Mots-clé
Adult Aged Blood Pressure/drug effects Dose-Response Relationship, Drug Epinephrine/blood Female Heart Rate/drug effects Humans Hypothyroidism/*physiopathology Male Middle Aged Norepinephrine/blood Phenylephrine/*pharmacology Thyroid Gland/drug effects/metabolism Thyroxine/pharmacology Triiodothyronine/metabolism
Pubmed
Web of science
Création de la notice
25/01/2008 14:00
Dernière modification de la notice
20/08/2019 13:18
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