Antiretrovirale Medikamente und Schwangerschaft [Antiretroviral therapy and pregnancy].

Détails

ID Serval
serval:BIB_32ECFD3572BC
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Antiretrovirale Medikamente und Schwangerschaft [Antiretroviral therapy and pregnancy].
Périodique
Therapeutische Umschau. Revue Thérapeutique
Auteur(s)
Wunder D., Evison J.M.
ISSN
0040-5930 (Print)
ISSN-L
0040-5930
Statut éditorial
Publié
Date de publication
2005
Volume
62
Numéro
1
Pages
37-42
Langue
allemand
Notes
Publication types: English Abstract ; Journal Article ; Review
Résumé
Whereas the perinatal transmission rate with untreated HIV positive women is around 30%, the results of Pediatric AIDS Clinical Trials Group in 1994 showed a reduction by nearly 70% with Zidovudin chemoprophylaxis. The transmission rate can even be reduced to under 2%, if a cesarean section before onset of labour and before premature rupture of membranes is done in addition. An individualized, optimal antiretroviral combination therapy, ideally introduced in the second trimenon (in special cases even already in the first trimenon), is of great importance. As a further strategy of prevention of perinatal transmission, intravenous Zidovudin chemoprophylaxis should be given in addition to the mother during labour and to the newborn during the first six weeks of life. Besides very few exceptions, long-term data after intrauterine administration of antiretroviral therapy do not show any teratogen or other long term consequences to date. The situation in developing countries is very critical with still high transmission rates because of the lack of antiretroviral therapy due to logistical reasons and costs and the need of breastfeeding. For these reasons, more and more feasible short protocols are developed with at least fifty percent reduction of neonatal transmission rates.
Mots-clé
Anti-HIV Agents/adverse effects, Anti-HIV Agents/therapeutic use, Anti-Retroviral Agents/administration & dosage, Anti-Retroviral Agents/adverse effects, Female, HIV Infections/embryology, HIV Infections/prevention & control, Humans, Infectious Disease Transmission, Vertical/prevention & control, Maternal-Fetal Exchange/drug effects, Physician's Practice Patterns, Practice Guidelines as Topic, Pregnancy, Pregnancy Complications, Infectious/drug therapy, Risk Assessment/methods, Risk Factors, Treatment Outcome, Women's Health, Zidovudine/administration & dosage, Zidovudine/adverse effects
Pubmed
Création de la notice
19/03/2012 11:25
Dernière modification de la notice
20/08/2019 14:18
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