Imbalance between tumour necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. The J5 Study Group

Détails

ID Serval
serval:BIB_32CABDDB4663
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Imbalance between tumour necrosis factor-alpha and soluble TNF receptor concentrations in severe meningococcaemia. The J5 Study Group
Périodique
Immunology
Auteur(s)
Girardin  E., Roux-Lombard  P., Grau  G. E., Suter  P., Gallati  H., Dayer  J. M.
ISSN
0019-2805
Statut éditorial
Publié
Date de publication
05/1992
Peer-reviewed
Oui
Volume
76
Numéro
1
Pages
20-3
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: May
Résumé
The extracellular domain of tumour necrosis factor-alpha (TNF-alpha) receptors have inhibitory properties against TNF-alpha. The relative ratio between ligand and ligand inhibitors may influence the outcome of meningococcaemia. To test this hypothesis, levels of TNF-alpha and of each of the soluble inhibitory fragments originating from two distinct TNF-alpha receptors (sTNF-RI and sTNF-RII) were measured in sera of children with severe meningococcaemia. On admission to the hospital the levels of sTNF-RI, -RII and TNF-alpha were markedly increased and all three correlated with the outcome of the disease. A correlation was found between TNF-alpha and sTNF-RI (P less than 0.001 by Pearson rank correlation coefficient) or sTNF-RII (P = 0.012). For TNF-alpha concentrations below 500 pg/ml, the increase of TNF-alpha was proportional to that of sTNF-RI and RII; however, when TNF-alpha levels exceeded 500 pg/ml, sTNF-RI and RII concentrations did not increase proportionally. At admission, in patients with fatal outcome, the ratios TNF-alpha/sTNF-RI and -RII were higher than in survivors. During the first 6 hr, the kinetics of TNF-alpha, sTNF-RI and -RII were different. Naturally occurring TNF-alpha inhibitors may play an important role in modulating the biological activity of TNF-alpha in severe meningococcaemia.
Mots-clé
Bacteremia/*blood Child Child, Preschool Humans Interleukin-6/metabolism Meningitis, Meningococcal/*blood/immunology/mortality Prognosis Receptors, Cell Surface/*metabolism Receptors, Tumor Necrosis Factor Tumor Necrosis Factor-alpha/*metabolism
Pubmed
Web of science
Création de la notice
15/01/2008 14:27
Dernière modification de la notice
20/08/2019 13:18
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