Role of interferon-gamma in contact hypersensitivity assessed in interferon-gamma receptor-deficient mice.

Détails

ID Serval
serval:BIB_32BE4B6823B8
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Role of interferon-gamma in contact hypersensitivity assessed in interferon-gamma receptor-deficient mice.
Périodique
Toxicology
Auteur(s)
Saulnier M., Huang S., Aguet M., Ryffel B.
ISSN
0300-483X (Print)
ISSN-L
0300-483X
Statut éditorial
Publié
Date de publication
1995
Volume
102
Numéro
3
Pages
301-312
Langue
anglais
Résumé
The role of interferon-gamma (IFN gamma) in contact hypersensitivity induced by the haptens, oxazolone and 2,4,6-trinitrochlorobenzene (TNCB), was investigated in mice with a targeted disruption of the IFN gamma receptor (IFN gamma-R-/-). The 24-h ear-swelling response to oxazolone or TNCB in sensitized animals was not significantly reduced by the disruption of IFN gamma signalling. Dermal mononuclear infiltrates (MN) and epidermal microabscesses, however, were clearly diminished in the mutant mice. The hapten-induced upregulation of intercellular-adhesion molecule-1 (ICAM-1) and major histocompatibility complex (MHC) class I in IFN gamma-R-/- mice was smaller when compared to wild-type mice. It is concluded that oxazolone- and TNCB-induced contact hypersensitivity is partially dependent on a functional IFN gamma system. While the cutaneous oedema is IFN gamma-independent, the mononuclear cell infiltration and epidermal microabscess formation are at least partly IFN gamma-dependent. Therefore, reduced cellular infiltrates are likely due to a reduced upregulation of ICAM-1 and class I antigen expression in IFN gamma-R-/- mice.
Mots-clé
Adjuvants, Immunologic/toxicity, Animals, Dermatitis, Contact/immunology, Dermatitis, Contact/pathology, Female, Genotype, Haptens/toxicity, Histocompatibility Antigens Class II/drug effects, Interferon-gamma/physiology, Major Histocompatibility Complex/drug effects, Male, Mice, Mice, Inbred Strains, Oxazolone/toxicity, Picryl Chloride/toxicity, Receptors, Interferon/deficiency, Up-Regulation
Pubmed
Web of science
Création de la notice
28/01/2008 11:36
Dernière modification de la notice
20/08/2019 13:18
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