Forensic significance of postmortem estimation of the blood cerebrospinal fluid barrier permeability.

Détails

ID Serval
serval:BIB_32A08E3A4F47
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Forensic significance of postmortem estimation of the blood cerebrospinal fluid barrier permeability.
Périodique
Forensic Science International
Auteur(s)
Mangin P., Lugnier A.A., Chaumont A.J., Offner M., Grucker M.
ISSN
0379-0738[print], 0379-0738[linking]
Statut éditorial
Publié
Date de publication
1983
Volume
22
Numéro
2-3
Pages
143-149
Langue
anglais
Résumé
Albumin concentration in cerebrospinal fluid (CSF) and plasma was determined in 44 cadavers divided into three groups on the basis of death agony duration. The same was determined in a control group of 42 patients with no demonstrable neurological disease. Following Schuller's method, the evaluation of the blood CSF barrier permeability was based upon the rate of albumin transfer from plasma to CSF. An average increase of 9% in blood CSF barrier permeability was found in cases of a long-duration death agony but not in cases of short-duration death agony (sudden deaths) or in the control group. We consider these results to be related to the hypoxia and hypercapnia which characterize the agonic suffering period. Therefore, we conclude that the postmortem determination of the rate of albumin transfer from plasma to CSF could be a reliable indicator of the duration of the agonic process.
Mots-clé
Adolescent, Adult, Aged, Albumins/cerebrospinal fluid, Blood-Brain Barrier, Cadaver, Capillary Permeability, Child, Child, Preschool, Death, Sudden, Forensic Medicine, Humans, Middle Aged, Serum Albumin/analysis, Time Factors
Pubmed
Création de la notice
11/10/2010 16:09
Dernière modification de la notice
20/08/2019 14:18
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