[(18)F]FDG PET signal is driven by astroglial glutamate transport.

Détails

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Etat: Public
Version: Author's accepted manuscript
Licence: Non spécifiée
ID Serval
serval:BIB_326B11D79CDB
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
[(18)F]FDG PET signal is driven by astroglial glutamate transport.
Périodique
Nature neuroscience
Auteur(s)
Zimmer E.R., Parent M.J., Souza D.G., Leuzy A., Lecrux C., Kim H.I., Gauthier S., Pellerin L., Hamel E., Rosa-Neto P.
ISSN
1546-1726 (Electronic)
ISSN-L
1097-6256
Statut éditorial
Publié
Date de publication
03/2017
Peer-reviewed
Oui
Volume
20
Numéro
3
Pages
393-395
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Contributions of glial cells to neuroenergetics have been the focus of extensive debate. Here we provide positron emission tomography evidence that activation of astrocytic glutamate transport via the excitatory amino acid transporter GLT-1 triggers widespread but graded glucose uptake in the rodent brain. Our results highlight the need for a reevaluation of the interpretation of [(18)F]FDG positron emission tomography data, whereby astrocytes would be recognized as contributing to the [(18)F]FDG signal.
Mots-clé
Animals, Astrocytes/metabolism, Biological Transport, Brain/blood supply, Brain/drug effects, Brain/metabolism, Ceftriaxone/pharmacology, Cells, Cultured, Excitatory Amino Acid Transporter 1/agonists, Excitatory Amino Acid Transporter 1/physiology, Fluorodeoxyglucose F18/metabolism, Functional Neuroimaging, Glutamic Acid/metabolism, Locomotion/drug effects, Male, Positron-Emission Tomography, Rats, Vibrissae/physiology
Pubmed
Web of science
Création de la notice
07/02/2017 19:19
Dernière modification de la notice
30/04/2021 7:09
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