Adults with attention-deficit/hyperactivity disorder - a diffusion-tensor imaging study of the corpus callosum.

Détails

ID Serval
serval:BIB_3269BE9F2463
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Adults with attention-deficit/hyperactivity disorder - a diffusion-tensor imaging study of the corpus callosum.
Périodique
Psychiatry research
Auteur(s)
Dramsdahl M., Westerhausen R., Haavik J., Hugdahl K., Plessen K.J.
ISSN
0165-1781 (Print)
ISSN-L
0165-1781
Statut éditorial
Publié
Date de publication
28/02/2012
Peer-reviewed
Oui
Volume
201
Numéro
2
Pages
168-173
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
The objective of the present study was to investigate the microstructure and the macrostructure of the corpus callosum (CC) in adults with Attention-Deficit/Hyperactivity Disorder (ADHD) by means of magnetic resonance imaging (MRI). Twenty-nine participants with ADHD and 37 controls were included from the Norwegian ADHD project in Bergen. We measured the fractional anisotropy (FA) values, as well as the size of different subdivisions of the CC, using diffusion tensor imaging (DTI) and anatomical MRI. The isthmus/splenium part of the CC in the ADHD group showed reduced FA values compared to the control group, whereas the size of the CC did not differ across groups. Our findings thus demonstrate a divergence between microstructural and macrostructural measures in the CC of adults with ADHD. This contrasts with findings in children demonstrating callosal abnormalities in both microstructure and macrostructure. Our results may indicate that adults with ADHD in part have succeeded in passing by an earlier developmental delay of the CC, resulting in a normalization of callosal macrostructure into adulthood. However, microstructural differences are still present in adults, which may point to an abnormal lateralization in adults with ADHD, or could be a sign of a persisting impairment.
Mots-clé
Adult, Age Factors, Anisotropy, Attention Deficit Disorder with Hyperactivity/diagnosis, Attention Deficit Disorder with Hyperactivity/pathology, Brain Mapping, Corpus Callosum/pathology, Developmental Disabilities/pathology, Diffusion Magnetic Resonance Imaging, Dominance, Cerebral/physiology, Female, Humans, Image Interpretation, Computer-Assisted, Male, Middle Aged, Norway, Reference Values, Young Adult
Pubmed
Web of science
Création de la notice
14/02/2019 10:46
Dernière modification de la notice
20/08/2019 14:18
Données d'usage