Preferential V delta 1 expression among TcR gamma/delta-bearing T cells in human oral epithelium

Détails

ID Serval
serval:BIB_3269012DECA2
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Preferential V delta 1 expression among TcR gamma/delta-bearing T cells in human oral epithelium
Périodique
Scandinavian Journal of Immunology
Auteur⸱e⸱s
Pepin  L. F., Roger  T., Morisset  J., Seman  M.
ISSN
0300-9475 (Print)
Statut éditorial
Publié
Date de publication
03/1993
Volume
37
Numéro
3
Pages
289-94
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Mar
Résumé
The oral cavity is a septic area colonized by various bacterial species, and the oral mucosa is frequently submitted to microtraumas. Several mechanisms are implicated in the defence of the oral tissue, but little is known concerning the eventual presence and role of gamma/delta T cells at this site. Samples of healthy keratinized oral mucosa were examined with immunochemical techniques using anti-CD3, CD4, CD8, CD22, TcR delta 1, V delta 1 and V delta 2 monoclonal antibodies. Whatever the site examined, gamma/delta T cells represent at most 2% of the T-cell population, a value similar to that found in other tissues. In the connective tissue, under the basement membrane, V delta 2+ gamma/delta T cells are predominant whereas the epithelium mostly contains V delta 1+ gamma/delta T cells. The significance of this preferential V delta 1 intraepithelial presence is discussed.
Mots-clé
B-Lymphocytes/physiology Epithelial Cells Epithelium/immunology Gene Expression Gene Rearrangement, delta-Chain T-Cell Antigen Receptor Humans Mouth Mucosa/cytology/*immunology Receptors, Antigen, T-Cell, gamma-delta/genetics/*metabolism T-Lymphocyte Subsets/*physiology
Pubmed
Web of science
Création de la notice
25/01/2008 14:35
Dernière modification de la notice
20/08/2019 14:18
Données d'usage