Metabolism of complement factor D in renal failure

Détails

ID Serval
serval:BIB_32147200193E
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Metabolism of complement factor D in renal failure
Périodique
Kidney International
Auteur(s)
Pascual  M., Steiger  G., Estreicher  J., Macon  K., Volanakis  J. E., Schifferli  J. A.
ISSN
0085-2538
Statut éditorial
Publié
Date de publication
10/1988
Peer-reviewed
Oui
Volume
34
Numéro
4
Pages
529-36
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Oct
Résumé
Factor D is an essential enzyme of the alternative pathway of complement. Its plasma concentration increases approximately tenfold in end-stage renal failure (ESRF). To analyze its metabolism in humans, we injected purified radiolabelled factor D into 5 healthy individuals and 12 patients with various renal diseases or renal failure. Fractional metabolic rates (FMR) and extravascular/intravascular distributions (EV/IV) were calculated using a compartmental model. The FMR was very rapid in normal individuals (mean 59.6%/hr; range 74.1 to 50.5), significantly diminished in the five patients with ESRF (5.7%/hr; 7.0 to 2.8; P less than 0.004), and correlated well with the creatinine clearance (r = 0.89; P less than 0.001). The extrarenal catabolic rate was not modified in renal failure. Despite a significant inverse correlation between plasma levels of factor D and creatinine clearance [r = 0.68; P less than 0.002], factor D levels were not a sensitive indicator of renal function because the synthesis rate (SR) varied widely from one individual to another (mean SR: 62.9 micrograms/kg/hr; 14.9 to 136.5). Factor D synthesis was not significantly altered by renal function, and did not correlate with C-reactive protein, suggesting that factor D is not an acute phase protein. The proportion of intact factor D elimination in the urine was increased in patients with tubular dysfunction (up to 15% compared to less than 0.2% in normal individuals) confirming that under normal circumstances factor D is filtered through the glomerulus and catabolized by tubular cells.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Complement Activating Enzymes/*metabolism Complement C3/metabolism Complement Factor D/*metabolism Complement Pathway, Alternative Creatinine/metabolism Humans Kidney Diseases/*metabolism
Pubmed
Web of science
Open Access
Oui
Création de la notice
29/01/2008 14:53
Dernière modification de la notice
20/08/2019 14:17
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