Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice

Détails

ID Serval
serval:BIB_320E214CA10F
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Therapeutic effect of anti-L3T4 monoclonal antibody GK1.5 on cutaneous leishmaniasis in genetically-susceptible BALB/c mice
Périodique
Journal of Immunology
Auteur(s)
Titus  R. G., Ceredig  R., Cerottini  J. C., Louis  J. A.
ISSN
0022-1767 (Print)
Statut éditorial
Publié
Date de publication
09/1985
Volume
135
Numéro
3
Pages
2108-14
Notes
Journal Article
Research Support, Non-U.S. Gov't --- Old month value: Sep
Résumé
The effect of in vivo treatment with anti-L3T4 monoclonal antibody (mAb) on the course of experimentally-induced cutaneous leishmaniasis was studied in genetically susceptible BALB/c mice. Administration of anti-L3T4 mAb resulted in a pronounced therapeutic effect as reflected by both resolution of lesions and a dramatic reduction in the parasite load in treated mice. This effect was specific for anti-L3T4 mAb and correlated with a selective depletion of L3T4+ T cells in the lymphoid tissues of treated mice. Moreover, both the therapeutic effect of anti-L3T4 mAb on cutaneous leishmaniasis and the concurrent depletion of L3T4+ T cells in the lymphoid tissues of treated mice were dependent upon the isotype of the anti-L3T4 mAb employed.
Mots-clé
Animals Antibodies, Monoclonal/*therapeutic use Antigens, Differentiation, T-Lymphocyte Antigens, Surface/*immunology Cytotoxicity, Immunologic Leishmaniasis/immunology/*therapy Macrophages/immunology Mice Mice, Inbred BALB C/immunology Mice, Nude/immunology T-Lymphocytes/*immunology
Pubmed
Web of science
Création de la notice
28/01/2008 12:14
Dernière modification de la notice
20/08/2019 14:17
Données d'usage