Trace lithium in mood disorders

Détails

ID Serval
serval:BIB_31FC4B97AC47
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Trace lithium in mood disorders
Périodique
Journal of Affective Disorders
Auteur(s)
Dafflon  M., Decosterd  L. A., Biollaz  J., Preisig  M., Dufour  H., Buclin  T.
ISSN
0165-0327 (Print)
Statut éditorial
Publié
Date de publication
07/1999
Peer-reviewed
Oui
Volume
54
Numéro
1-2
Pages
199-203
Notes
Journal Article Research Support, Non-U.S. Gov't --- Old month value: Jul
Résumé
BACKGROUND: Variations in trace (endogenous) lithium exchanges have been postulated to play a role in the pathophysiology of affective diseases. This prospective study aimed to check whether plasma, erythrocytes and urine trace lithium levels were altered in mood disorders. METHODS: Trace lithium was determined by atomic absorption spectrophotometry in patients without mood stabilizing drugs or somatic diseases, hospitalized for bipolar affective disorders, major depressive episodes, and other psychiatric disorders with depressive features. Patients admitted for psychotic disorders without mood alterations and healthy volunteers served as controls. RESULTS: There were no differences in trace lithium status between the groups. Erythrocytes/plasma ratios appeared higher than described on therapeutic lithium (1.6+/-0.7, N = 199). LIMITATIONS: The study had sufficient power to detect clinically significant differences in whole body lithium handling between the groups. However, it did not address alterations of lithium exchanges across neuronal membranes or the blood-brain barrier. CONCLUSIONS: Alterations of membrane exchanges hypothetically associated with mood disorders are not reflected in plasma or erythrocytes trace lithium levels. The occurrence of mood disorders seems not to be related to abnormalities in endogenous lithium.
Mots-clé
Antimanic Agents/*metabolism/therapeutic use Cell Membrane/metabolism Erythrocytes/*metabolism Humans Lithium/*metabolism/therapeutic use Mood Disorders/drug therapy/*metabolism Prospective Studies Questionnaires Spectrophotometry, Atomic/*methods
Pubmed
Web of science
Création de la notice
25/01/2008 11:41
Dernière modification de la notice
20/08/2019 14:17
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