Acquired auditory agnosia in childhood and normal sleep electroencephalography subsequently diagnosed as Landau-Kleffner syndrome: a report of three cases.

Détails

ID Serval
serval:BIB_31AC9A670F43
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Etude de cas (case report): rapporte une observation et la commente brièvement.
Collection
Publications
Institution
Titre
Acquired auditory agnosia in childhood and normal sleep electroencephalography subsequently diagnosed as Landau-Kleffner syndrome: a report of three cases.
Périodique
Developmental Medicine and Child Neurology
Auteur(s)
Van Bogaert P., King M.D., Paquier P., Wetzburger C., Labasse C., Dubru J.M., Deonna T.
ISSN
1469-8749 (Electronic)
ISSN-L
0012-1622
Statut éditorial
Publié
Date de publication
2013
Volume
55
Numéro
6
Pages
575-579
Langue
anglais
Notes
Publication types: JOURNAL ARTICLEPublication Status: ppublish. PDF type: Case report
Résumé
Aim  We report three cases of Landau-Kleffner syndrome (LKS) in children (two females, one male) in whom diagnosis was delayed because the sleep electroencephalography (EEG) was initially normal. Method  Case histories including EEG, positron emission tomography findings, and long-term outcome were reviewed. Results  Auditory agnosia occurred between the age of 2 years and 3 years 6 months, after a period of normal language development. Initial awake and sleep EEG, recorded weeks to months after the onset of language regression, during a nap period in two cases and during a full night of sleep in the third case, was normal. Repeat EEG between 2 months and 2 years later showed epileptiform discharges during wakefulness and strongly activated by sleep, with a pattern of continuous spike-waves during slow-wave sleep in two patients. Patients were diagnosed with LKS and treated with various antiepileptic regimens, including corticosteroids. One patient in whom EEG became normal on hydrocortisone is making significant recovery. The other two patients did not exhibit a sustained response to treatment and remained severely impaired. Interpretation  Sleep EEG may be normal in the early phase of acquired auditory agnosia. EEG should be repeated frequently in individuals in whom a firm clinical diagnosis is made to facilitate early treatment.
Pubmed
Web of science
Création de la notice
31/05/2013 17:06
Dernière modification de la notice
20/08/2019 14:17
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