Nouvelles strategies dans le traitement du retinoblastome. [New strategies in the management of retinoblastoma]

Détails

ID Serval
serval:BIB_31A23C460404
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Nouvelles strategies dans le traitement du retinoblastome. [New strategies in the management of retinoblastoma]
Périodique
Journal Français d'Ophtalmologie
Auteur(s)
Balmer  A., Munier  F., Zografos  L.
ISSN
0181-5512 (Print)
Statut éditorial
Publié
Date de publication
02/2002
Volume
25
Numéro
2
Pages
187-93
Notes
Comparative Study
English Abstract
Journal Article
Review --- Old month value: Feb
Résumé
It was rare that a child survived retinoblastoma at the beginning of the twentieth century. Today the survival rate is in the order of 95% in reference centers, with new strategies improving prognosis step by step. Systematic enucleation used to be the starting point of any true and structured management, until the advent of radiotherapy made it possible not only to save lives but also to retain some useful vision. Early diagnosis has enabled focal therapies such as photocoagulation, cryocoagulation, and radioactive applicators to open up a new era of targeted tumor treatment. However, the onset of nonocular tumors secondary to radiotherapy, the resistance of certain tumors to irradiation, and unsightly cosmetic consequences all justify research into alternative therapeutic strategies. New types of chemotherapy have shown spectacular results and are currently under study: chemoreduction to make large tumors more manageable and enable less aggressive treatment of tumors located in delicate sites, thermochemotherapy using the effect of heat on plasma membrane permeability to antimitotics, and chemotherapy associated with cyclosporine to reduce the multidrug resistance of certain tumors. The aim is to avoid primary enucleation and external beam radiation as far as possible. The future may lie in local chemotherapy, hyperthermia, and dynamic phototherapy, accelerated proton beam radiotherapy also has promising prospects.
Mots-clé
Antineoplastic Agents/administration & dosage/therapeutic use Antineoplastic Agents, Phytogenic/administration & dosage/therapeutic use Antineoplastic Combined Chemotherapy Protocols/therapeutic use Carboplatin/administration & dosage/therapeutic use Etoposide/administration & dosage/therapeutic use Eye Enucleation Eye, Artificial Female Fluorescein Angiography Follow-Up Studies Forecasting Gene Therapy Humans Hyperthermia, Induced Infant Infant, Newborn Male Neoadjuvant Therapy Retinal Neoplasms/diagnosis/drug therapy/mortality/radiotherapy/*therapy Retinoblastoma/diagnosis/drug therapy/mortality/radiotherapy/*therapy Time Factors
Pubmed
Web of science
Création de la notice
28/01/2008 13:54
Dernière modification de la notice
20/08/2019 14:17
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