The age at onset of diabetes influences functional and structural changes in the pituitary-thyroid axis of streptozocin-diabetic male rats

Détails

ID Serval
serval:BIB_3182C49F6D38
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
The age at onset of diabetes influences functional and structural changes in the pituitary-thyroid axis of streptozocin-diabetic male rats
Périodique
Virchows Archiv. B, Cell Pathology Including Molecular Pathology
Auteur(s)
Tontis  D. K., Bestetti  G. E., Reymond  M. J., Lemarchand-Beraud  T., Rossi  G. L.
ISSN
0340-6075
Statut éditorial
Publié
Date de publication
1990
Volume
59
Numéro
4
Pages
205-13
Notes
Journal Article
Research Support, Non-U.S. Gov't
Résumé
Severe structural changes leading to marked alterations in secretory activity are known to occur in the pituitary-thyroid axis 1 month after induction of postpuberal streptozocin (SZ)-diabetes. However, SZ-diabetic rats of different age groups have not been compared, nor has the maturity of the pituitary and thyroid glands at the onset of diabetes been correlated with the type and evolution of functional and structural changes. We thus induced diabetes in 1-month (prepuberal of 3-month (postpuberal) old male rats and compared diabetic with control groups 4 and 8 months after SZ or saline injection. We determined: 1) pituitary and thyroid weights, 2) the basal plasma TSH, T3, and T4 concentrations, and 3) several morphometrical measurements in the pituitary and thyroid glands. After 4 months, 1) the pituitary and thyroid weights were decreased, 2) plasma TSH and T3 were unchanged, plasma T4 was reduced. and 3) the number of thyrotropes, degenerative changes of follicle cells, and colloid area were increased, the follicle cell height as well as the number of fused cold follicles decreased, and the follicle area was unchanged in diabetic compared with control rats. The lesions were more conspicuous in pre- than in postpuberal diabetic animals. After 8 months, plasma TSH, T3, and T4 were decreased in diabetic compared with control rats. Except for the increased colloid area, all other lesions were similar, though more severe in prepuberal diabetic rats after 8 than 4 months. Few changes were found in postpuberal diabetic rats.(ABSTRACT TRUNCATED AT 250 WORDS)
Mots-clé
Aging Animals Diabetes Mellitus, Experimental/*pathology Male Pituitary Gland/*pathology Rats Rats, Inbred Strains Thyroid Gland/*pathology
Pubmed
Web of science
Création de la notice
11/02/2008 15:12
Dernière modification de la notice
20/08/2019 14:16
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