Le renouveau du thalidomide. Un vieux medicament aux nouvelles indications. [The revival of thalidomide: an old drug with new indications]

Détails

ID Serval
serval:BIB_313578B2381C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Le renouveau du thalidomide. Un vieux medicament aux nouvelles indications. [The revival of thalidomide: an old drug with new indications]
Périodique
Revue du Praticien
Auteur(s)
Laffitte  E.
ISSN
0035-2640 (Print)
Statut éditorial
Publié
Date de publication
11/2006
Volume
56
Numéro
18
Pages
1977-83
Notes
English Abstract
Journal Article
Review --- Old month value: Nov 30
Résumé
Thalidomide has several mechanisms of action: several immuno-modulatory properties, an anti-angiogenic action and a hypnosedative effect. Thalidomide has been used in several cutaneous inflammatory disorders (such as erythema nodosum leprosum in lepromatous leprosy, cutaneous lupus erythematosus, severe aphtosis), cancers (relapsed/refractory multiple myeloma) and inflammatory conditions. Several side effects are associated with thalidomide; some are major: teratogenicity, peripheral neuropathy and deep venous thrombosis; some are minor, such as somnolence or abdominal pain and endocrinologic disturbances. Use of thalidomide is strictly controlled with close adherence to a birth control program and close monitoring for early development of peripheral neuropathy.
Mots-clé
Angiogenesis Inhibitors/pharmacology/*therapeutic use Drug Eruptions Humans Leprostatic Agents/pharmacology/*therapeutic use Peripheral Nervous System Diseases/chemically induced Skin Diseases/drug therapy Teratogens/pharmacology Thalidomide/pharmacology/*therapeutic use Thrombosis/chemically induced
Pubmed
Création de la notice
25/01/2008 16:41
Dernière modification de la notice
20/08/2019 13:16
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