Infarctus cérébraux artériels d'origine hématologique: expérience lausannoise et revue de la littérature [Cerebral infarction of arterial origin and haematological causation: the Lausanne experience and a review of the literature]

Détails

ID Serval
serval:BIB_31353
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Infarctus cérébraux artériels d'origine hématologique: expérience lausannoise et revue de la littérature [Cerebral infarction of arterial origin and haematological causation: the Lausanne experience and a review of the literature]
Périodique
Revue Neurologique
Auteur(s)
Gonthier A., Bogousslavsky J.
ISSN
0035-3787
Statut éditorial
Publié
Date de publication
2004
Volume
160
Numéro
11
Pages
1029-1039
Langue
français
Notes
Publication types: English Abstract ; Journal Article ; Review
Résumé
INTRODUCTION: Hematological diseases are seldom found as the etiology of ischemic strokes, but are frequently investigated by expensive laboratory tests after a first cerebral vascular event. METHODS: In the Lausanne Stroke Registry, we retrospectively reviewed the cases of patients hospitalized between 1979 and 2001 for a first ischemic arterial stroke which was attributed to a hematological etiology. Of 4697 patients, 22 (0.47 per cent) had a stroke due to one of the following hematological pathology: polycythemia vera (4), secondary polycythemia (4), essential thrombocytemia (2), secondary thrombocytosis (4), multiple myeloma (1), CIVD (1), protein S deficiency (1), antiphospholipid antibody syndrome (4), moderate homocysteinemia (1). A literature review was undertaken for each hemopathy. CONCLUSION: In light of the results of these data, we concluded that a complete blood count provides sufficient hematological screening for the majority of patients hospitalized for an arterial stroke. The antiphospholipid antibody syndrome is a rare cause of cerebral infarction, which needs to be investigated in young patients, in cases of multiple or recurring stroke or in the presence of a typical history. Inherited thrombophilias are not a significant risk factor for arterial cerebral infarction and their investigation is only warranted for a sub-group of young patients with a cryptogenic stroke, in which group the prevalence is slightly increased. Moderate homocysteinemia must be considered as a cerebrovascular risk factor of minor importance, but potentially treatable by a substitution of vitamin B12, B6 and folates. The efficacy of this substitution in the prevention of cardiovascular events needs yet to be demonstrated.
Mots-clé
Adult, Aged, Aged, 80 and over, Antiphospholipid Syndrome/complications, Cerebral Infarction/etiology, Female, Hematologic Diseases/complications, Humans, Male, Middle Aged, Retrospective Studies, Switzerland, Thrombophilia/complications
Pubmed
Web of science
Création de la notice
19/11/2007 12:29
Dernière modification de la notice
20/08/2019 13:16
Données d'usage