Fixation times of de novo and standing beneficial variants in subdivided populations.
Détails
ID Serval
serval:BIB_3132BDAC5168
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Fixation times of de novo and standing beneficial variants in subdivided populations.
Périodique
Genetics
ISSN
1943-2631 (Electronic)
ISSN-L
0016-6731
Statut éditorial
Publié
Date de publication
05/06/2024
Peer-reviewed
Oui
Volume
227
Numéro
2
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Publication Status: ppublish
Résumé
The rate at which beneficial alleles fix in a population depends on the probability of and time to fixation of such alleles. Both of these quantities can be significantly impacted by population subdivision and limited gene flow. Here, we investigate how limited dispersal influences the rate of fixation of beneficial de novo mutations, as well as fixation time from standing genetic variation. We investigate this for a population structured according to the island model of dispersal allowing us to use the diffusion approximation, which we complement with simulations. We find that fixation may take on average fewer generations under limited dispersal than under panmixia when selection is moderate. This is especially the case if adaptation occurs from de novo recessive mutations, and dispersal is not too limited (such that approximately FST<0.2). The reason is that mildly limited dispersal leads to only a moderate increase in effective population size (which slows down fixation), but is sufficient to cause a relative excess of homozygosity due to inbreeding, thereby exposing rare recessive alleles to selection (which accelerates fixation). We also explore the effect of metapopulation dynamics through local extinction followed by recolonization, finding that such dynamics always accelerate fixation from standing genetic variation, while de novo mutations show faster fixation interspersed with longer waiting times. Finally, we discuss the implications of our results for the detection of sweeps, suggesting that limited dispersal mitigates the expected differences between the genetic signatures of sweeps involving recessive and dominant alleles.
Mots-clé
Models, Genetic, Selection, Genetic, Genetic Variation, Mutation, Genetics, Population, Alleles, Gene Flow, diffusion approximation, fixation time, inbreeding, kin competition, metapopulation, selective sweeps
Pubmed
Web of science
Création de la notice
02/04/2024 9:33
Dernière modification de la notice
15/06/2024 7:03