Progenitor cell recruitment during individualized high-flow, very-large-volume apheresis for autologous transplantation improves collection efficiency.

Détails

ID Serval
serval:BIB_30F05F482381
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Progenitor cell recruitment during individualized high-flow, very-large-volume apheresis for autologous transplantation improves collection efficiency.
Périodique
Transfusion
Auteur(s)
Fontana S., Groebli R., Leibundgut K., Pabst T., Zwicky C., Taleghani B.M.
ISSN
0041-1132 (Print)
ISSN-L
0041-1132
Statut éditorial
Publié
Date de publication
2006
Peer-reviewed
Oui
Volume
46
Numéro
8
Pages
1408-1416
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublish
Résumé
BACKGROUND: Individual adaptation of processed patient's blood volume (PBV) should reduce number and/or duration of autologous peripheral blood progenitor cell (PBPC) collections.
STUDY DESIGN AND METHODS: The durations of leukapheresis procedures were adapted by means of an interim analysis of harvested CD34+ cells to obtain the intended yield of CD34+ within as few and/or short as possible leukapheresis procedures. Absolute efficiency (AE; CD34+/kg body weight) and relative efficiency (RE; total CD34+ yield of single apheresis/total number of preapheresis CD34+) were calculated, assuming an intraapheresis recruitment if RE was greater than 1, and a yield prediction models for adults was generated.
RESULTS: A total of 196 adults required a total of 266 PBPC collections. The median AE was 7.99 x 10(6), and the median RE was 1.76. The prediction model for AE showed a satisfactory predictive value for preapheresis CD34+ only. The prediction model for RE also showed a low predictive value (R2 = 0.36). Twenty-eight children underwent 44 PBPC collections. The median AE was 12.13 x 10(6), and the median RE was 1.62. Major complications comprised bleeding episodes related to central venous catheters (n = 4) and severe thrombocytopenia of less than 10 x 10(9) per L (n = 16).
CONCLUSION: A CD34+ interim analysis is a suitable tool for individual adaptation of the duration of leukapheresis. During leukapheresis, a substantial recruitment of CD34+ was observed, resulting in a RE of greater than 1 in more than 75 percent of patients. The upper limit of processed PBV showing an intraapheresis CD34+ recruitment is higher than in a standard large-volume leukapheresis. Therefore, a reduction of individually needed PBPC collections by means of a further escalation of the processed PBV seems possible.
Mots-clé
Adolescent, Adult, Aged, Antigens, CD34, Catheters, Indwelling/adverse effects, Child, Child, Preschool, Hematopoietic Stem Cell Mobilization/adverse effects, Hemorrhage/etiology, Humans, Infant, Leukapheresis, Male, Middle Aged, Models, Biological, Peripheral Blood Stem Cell Transplantation/adverse effects, Predictive Value of Tests, Prospective Studies, Retrospective Studies, Thrombocytopenia/etiology, Transplantation, Autologous
Pubmed
Web of science
Création de la notice
09/11/2014 17:31
Dernière modification de la notice
20/08/2019 13:15
Données d'usage