Oxidative folding of proteins

Détails

ID Serval
serval:BIB_30ED6998DF9D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Oxidative folding of proteins
Périodique
Acc Chem Res
Auteur(s)
Narayan  M., Welker  E., Wedemeyer  W. J., Scheraga  H. A.
ISSN
0001-4842 (Print)
Statut éditorial
Publié
Date de publication
11/2000
Volume
33
Numéro
11
Pages
805-12
Notes
Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S. --- Old month value: Nov
Résumé
The oxidative folding of proteins is reviewed and illustrated with bovine pancreatic ribonuclease A (RNase A). The mutual effects of conformational folding and disulfide bond regeneration are emphasized, particularly the "locking in" of native disulfide bonds by stable tertiary structure in disulfide intermediates. Two types of structured metastable disulfide species are discerned, depending on the relative protection of their disulfide bonds and thiol groups. Four generic pathways for oxidative folding are identified and characterized.
Mots-clé
Animals Cattle Disulfides/chemistry Oxidation-Reduction *Protein Folding Ribonuclease, Pancreatic/chemistry
Pubmed
Web of science
Création de la notice
24/01/2008 14:40
Dernière modification de la notice
20/08/2019 13:15
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