Extent of hypoattenuation on CT angiography source images in basilar artery occlusion: prognostic value in the Basilar Artery International Cooperation Study.

Détails

ID Serval
serval:BIB_30CB1EB2DD66
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Extent of hypoattenuation on CT angiography source images in basilar artery occlusion: prognostic value in the Basilar Artery International Cooperation Study.
Périodique
Stroke
Auteur⸱e⸱s
Puetz V., Khomenko A., Hill M.D., Dzialowski I., Michel P., Weimar C., Wijman C.A., Mattle H.P., Engelter S.T., Muir K.W., Pfefferkorn T., Tanne D., Szabo K., Kappelle L.J., Algra A., von Kummer R., Demchuk A.M., Schonewille W.J.
Collaborateur⸱rice⸱s
Basilar Artery International Cooperation Study (BASICS) Group
Contributeur⸱rice⸱s
Schonewille WJ., van der Hoeven E., Kappelle LJ., Algra A., Mattle HP., Arnold M., Engelter ST., Wetzel S., Michel P., Puetz V., Khomenko A., Dzialowski I., von Kummer R., Weimar C., Michalski D., Weissenborn K., Haverkamp C., Pfefferkorn T., Szabo K., Groden C., Wijman CA., Hill MD., Demchuk AM., Muir K., MacDougall N., Tanne D., Orion D.
ISSN
1524-4628 (Electronic)
ISSN-L
0039-2499
Statut éditorial
Publié
Date de publication
2011
Peer-reviewed
Oui
Volume
42
Numéro
12
Pages
3454-3459
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't
Publication Status: ppublish
Résumé
BACKGROUND AND PURPOSE: The posterior circulation Acute Stroke Prognosis Early CT Score (pc-ASPECTS) quantifies the extent of early ischemic changes in the posterior circulation with a 10-point grading system. We hypothesized that pc-ASPECTS applied to CT angiography source images predicts functional outcome of patients in the Basilar Artery International Cooperation Study (BASICS).
METHODS: BASICS was a prospective, observational registry of consecutive patients with acute symptomatic basilar artery occlusion. Functional outcome was assessed at 1 month. We applied pc-ASPECTS to CT angiography source images of patients with CT angiography for confirmation of basilar artery occlusion. We calculated unadjusted and adjusted risk ratios (RRs) of pc-ASPECTS dichotomized at ≥8 versus <8. Primary outcome measure was favorable outcome (modified Rankin Scale scores 0-3). Secondary outcome measures were mortality and functional independence (modified Rankin Scale scores 0-2).
RESULTS: Of 158 patients included, 78 patients had a CT angiography source images pc-ASPECTS≥8. Patients with a pc-ASPECTS≥8 more often had a favorable outcome than patients with a pc-ASPECTS<8 (crude RR, 1.7; 95% CI, 0.98-3.0). After adjustment for age, baseline National Institutes of Health Stroke Scale score, and thrombolysis, pc-ASPECTS≥8 was not related to favorable outcome (RR, 1.3; 95% CI, 0.8-2.2), but it was related to reduced mortality (RR, 0.7; 95% CI, 0.5-0.98) and functional independence (RR, 2.0; 95% CI, 1.1-3.8). In post hoc analysis, pc-ASPECTS dichotomized at ≥6 versus <6 predicted a favorable outcome (adjusted RR, 3.1; 95% CI, 1.2-7.5).
CONCLUSIONS: pc-ASPECTS on CT angiography source images independently predicted death and functional independence at 1 month in the CT angiography subgroup of patients in the BASICS registry.
Mots-clé
Aged, Aged, 80 and over, Basilar Artery/radiography, Cerebral Angiography, Female, Humans, Male, Middle Aged, Predictive Value of Tests, Prognosis, Prospective Studies, Radiographic Image Interpretation, Computer-Assisted, Registries, Risk Factors, Tomography, X-Ray Computed, Vertebrobasilar Insufficiency/mortality, Vertebrobasilar Insufficiency/radiography
Pubmed
Web of science
Open Access
Oui
Création de la notice
27/10/2011 11:20
Dernière modification de la notice
20/08/2019 13:15
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