Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance.

Détails

ID Serval
serval:BIB_309FD7C8EC75
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Inflammation as a potential link between nonalcoholic fatty liver disease and insulin resistance.
Périodique
Journal of Endocrinology
Auteur⸱e⸱s
Asrih M., Jornayvaz F.R.
ISSN
1479-6805 (Electronic)
ISSN-L
0022-0795
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
218
Numéro
3
Pages
R25-R36
Langue
anglais
Notes
pdf : review
Résumé
Nonalcoholic fatty liver disease (NAFLD) has become a major health problem in developed countries. It has affected more than 30% of the general population and is commonly associated with insulin resistance, which is a major risk factor for the development of type 2 diabetes and a central feature of the metabolic syndrome. Furthermore, accumulating evidences reveal that NAFLD as well as insulin resistance is strongly related to inflammation. Cytokines and adipokines play a pivotal role in inflammatory processes. In addition, these inflammatory mediators regulate various functions including metabolic energy balance, inflammation, and immune response. However, their role in modulating ectopic lipids involved in the development of insulin resistance, such as diacylglycerols and ceramides, remains unknown. The aim of this review is first to describe the pathophysiology of insulin resistance in NAFLD. In particular, we discuss the role of ectopic lipid accumulation in the liver. Secondly, we also summarize recent findings emphasizing the role of main inflammatory markers in both NAFLD and insulin resistance and their potential role in modulating hepatic fat content in NAFLD and associated hepatic insulin resistance.
Mots-clé
Adipokines/immunology, Animals, Cytokines/immunology, Fatty Liver/immunology, Fatty Liver/metabolism, Humans, Insulin Resistance, Liver/immunology, Liver/metabolism, Non-alcoholic Fatty Liver Disease
Pubmed
Web of science
Open Access
Oui
Création de la notice
10/09/2015 12:04
Dernière modification de la notice
20/08/2019 13:15
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