Review of diagnostic challenges in occupational asthma

Détails

ID Serval
serval:BIB_3065F7194E10
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Review of diagnostic challenges in occupational asthma
Périodique
Current Allergy and Asthma Reports
Auteur(s)
Pralong Jacques A., Cartier André
ISSN
1534-6315 (Electronic)
ISSN-L
1529-7322
Statut éditorial
Publié
Date de publication
01/2017
Peer-reviewed
Oui
Volume
17
Numéro
1
Pages
[1-7]
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Occupational asthma (OA) is one of the most frequent occupational diseases and its diagnosis is often difficult. This review summarizes its current diagnostic challenges.
OA is associated with significant health and socio-economic burden. It is underdiagnosed and physicians need to adopt a stepwise approach to confirm the diagnosis. Although early removal from exposure to the offending agent is associated with a better prognosis, physicians should try to confirm the diagnosis of work-related asthma before taking a worker off work. A proper occupational and medical history is very important but is not enough to make the diagnosis of OA. Objective evidence of work-related asthma is required and this represents a serious challenge to most physicians. Measurement of non-specific bronchial responsiveness (NSBR) and spirometry may confirm the diagnosis of asthma but do not confirm the diagnosis of OA. Serial monitoring of peak expiratory flows (PEF), NSBR, and airway inflammation at and off work may confirm the diagnosis of OA but are often difficult to perform. Confirming sensitization by skin prick tests or specific IgE may help to support the diagnosis of OA. Specific inhalation challenges (SIC) in the lab or at work are considered the reference standard but are of limited access. Medical surveillance programs along with primary prevention (reducing exposure) may help to reduce the burden of OA, but the ideal program has yet to be defined. The diagnostic workup of OA remains a challenge and needs a rigorous stepwise evaluation.

Mots-clé
Asthma, Occupational/diagnosis, Humans, Occupational Exposure/adverse effects, Skin Tests/methods, Monitoring, Occupational asthma, Peak expiratory flow, Specific inhalation challenges
Pubmed
Web of science
Création de la notice
23/08/2017 15:29
Dernière modification de la notice
20/08/2019 14:15
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