Rapid Noninvasive Skin Monitoring by Surface Mass Recording and Data Learning.

Détails

ID Serval
serval:BIB_2FC489BC0711
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Rapid Noninvasive Skin Monitoring by Surface Mass Recording and Data Learning.
Périodique
JACS Au
Auteur(s)
Zhu Y., Lesch A., Li X., Lin T.E., Gasilova N., Jović M., Pick H.M., Ho P.C., Girault H.H.
ISSN
2691-3704 (Electronic)
ISSN-L
2691-3704
Statut éditorial
Publié
Date de publication
24/05/2021
Peer-reviewed
Oui
Volume
1
Numéro
5
Pages
598-611
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
Skin problems are often overlooked due to a lack of robust and patient-friendly monitoring tools. Herein, we report a rapid, noninvasive, and high-throughput analytical chemical methodology, aiming at real-time monitoring of skin conditions and early detection of skin disorders. Within this methodology, adhesive sampling and laser desorption ionization mass spectrometry are coordinated to record skin surface molecular mass in minutes. Automated result interpretation is achieved by data learning, using similarity scoring and machine learning algorithms. Feasibility of the methodology has been demonstrated after testing a total of 117 healthy, benign-disordered, or malignant-disordered skins. Remarkably, skin malignancy, using melanoma as a proof of concept, was detected with 100% accuracy already at early stages when the lesions were submillimeter-sized, far beyond the detection limit of most existing noninvasive diagnosis tools. Moreover, the malignancy development over time has also been monitored successfully, showing the potential to predict skin disorder progression. Capable of detecting skin alterations at the molecular level in a nonsurgical and time-saving manner, this analytical chemistry platform is promising to build personalized skin care.
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/06/2021 14:53
Dernière modification de la notice
19/06/2021 6:33
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