Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes.

Détails

ID Serval
serval:BIB_2F4F0820178B
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Molecular organization of the HLA-SB region of the human major histocompatibility complex and evidence for two SB beta-chain genes.
Périodique
Proceedings of the National Academy of Sciences of the United States of America
Auteur(s)
Gorski J., Rollini P., Long E., Mach B.
ISSN
0027-8424 (Print)
ISSN-L
0027-8424
Statut éditorial
Publié
Date de publication
1984
Volume
81
Numéro
13
Pages
3934-3938
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The class II products of the major histocompatibility complex, also called Ia antigens, are composed of two polypeptide chains, the alpha and beta chains, both encoded within the major histocompatibility complex. In man, the class II antigens can be divided into three biochemically distinct groups called HLA-DR, HLA-DC, and HLA-SB. Our isolation of cDNA clones for the polymorphic beta chain of HLA-DR and HLA-DC has allowed us to study the organization of the class II genes. Here we identify the HLA-SB beta-chain gene in recombinant clones from a cosmid library generated from a consanguineous homozygous B-cell line. The SB beta-chain gene is linked to the SB alpha-chain gene and the two genes are in opposite orientation. A second SB beta-chain gene, corresponding to a new SB beta II locus, has also been identified and cloned. The SB beta-chain genes show much less allelic restriction site polymorphism than the genes for the beta chains of HLA-DR or HLA-DC.
Mots-clé
Amino Acid Sequence, Base Sequence, Cloning, Molecular, DNA/analysis, DNA Restriction Enzymes, Genes, MHC Class II, HLA-DP Antigens, Histocompatibility Antigens Class II/analysis, Humans, Macromolecular Substances, Major Histocompatibility Complex, Nucleic Acid Hybridization, Plasmids
Pubmed
Web of science
Création de la notice
11/11/2011 11:16
Dernière modification de la notice
20/08/2019 13:13
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