The IC3D classification of the corneal dystrophies.
Détails
Télécharger: BIB_2F40B810736B.P001.pdf (5612.77 [Ko])
Etat: Public
Version: de l'auteur⸱e
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_2F40B810736B
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
The IC3D classification of the corneal dystrophies.
Périodique
Cornea
ISSN
1536-4798[electronic]
Statut éditorial
Publié
Date de publication
2008
Peer-reviewed
Oui
Volume
27 Suppl 2
Pages
S1-83
Langue
anglais
Notes
Publication types: Historical Article ; Journal Article ; Review - Publication Status: ppublish
Résumé
BACKGROUND: The recent availability of genetic analyses has demonstrated the shortcomings of the current phenotypic method of corneal dystrophy classification. Abnormalities in different genes can cause a single phenotype, whereas different defects in a single gene can cause different phenotypes. Some disorders termed corneal dystrophies do not appear to have a genetic basis. PURPOSE: The purpose of this study was to develop a new classification system for corneal dystrophies, integrating up-to-date information on phenotypic description, pathologic examination, and genetic analysis. METHODS: The International Committee for Classification of Corneal Dystrophies (IC3D) was created to devise a current and accurate nomenclature. RESULTS: This anatomic classification continues to organize dystrophies according to the level chiefly affected. Each dystrophy has a template summarizing genetic, clinical, and pathologic information. A category number from 1 through 4 is assigned, reflecting the level of evidence supporting the existence of a given dystrophy. The most defined dystrophies belong to category 1 (a well-defined corneal dystrophy in which a gene has been mapped and identified and specific mutations are known) and the least defined belong to category 4 (a suspected dystrophy where the clinical and genetic evidence is not yet convincing). The nomenclature may be updated over time as new information regarding the dystrophies becomes available. CONCLUSIONS: The IC3D Classification of Corneal Dystrophies is a new classification system that incorporates many aspects of the traditional definitions of corneal dystrophies with new genetic, clinical, and pathologic information. Standardized templates provide key information that includes a level of evidence for there being a corneal dystrophy. The system is user-friendly and upgradeable and can be retrieved on the website www.corneasociety.org/ic3d.
Mots-clé
Corneal Dystrophies, Hereditary/classification, Corneal Dystrophies, Hereditary/genetics, History, 19th Century, Humans, International Cooperation, Ophthalmology/trends, Phenotype, Terminology as Topic
Pubmed
Web of science
Open Access
Oui
Création de la notice
05/10/2009 16:44
Dernière modification de la notice
20/08/2019 14:13