Functional genomics approaches for the study of sporadic adrenal tumor pathogenesis: clinical implications

Détails

ID Serval
serval:BIB_2F20B3334262
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Functional genomics approaches for the study of sporadic adrenal tumor pathogenesis: clinical implications
Périodique
Journal of Steroid Biochemistry and Molecular Biology
Auteur(s)
Igaz  P., Wiener  Z., Szabo  P., Falus  A., Gaillard  R. C., Horanyi  J., Racz  K., Tulassay  Z.
ISSN
0960-0760 (Print)
Statut éditorial
Publié
Date de publication
10/2006
Volume
101
Numéro
2-3
Pages
87-96
Notes
Journal Article
Review --- Old month value: Oct
Résumé
Although sporadic adrenal tumors are frequently encountered in the general population their pathogenesis is not well elucidated. The advent of functional genomics/bioinformatics tools enabling large scale comprehensive genome expression profiling should contribute to significant progress in this field. Some studies have already been published describing gene expression profiles of benign and malignant adrenocortical tumors and phaeochromocytomas. Several genes coding for growth factors and their receptors, enzymes involved in steroid hormone biosynthesis, genes related to the regulation of cell cycle, cell proliferation, adhesion and intracellular metabolism have been found to be up- or downregulated in various tumors. Some alterations in gene expression appear so specific for certain tumor types that their application in diagnosis, determination of prognosis and the choice of therapy can be envisaged. In this short review, the authors will present a synopsis of these recent findings that seem to open new perspectives in adrenal tumor pathogenesis, with emphasis on changes in steroidogenic enzyme expression profiles and highlighting possible clinical implications.
Mots-clé
Adrenal Gland Neoplasms/etiology/*genetics/metabolism *Chromosome Aberrations Gene Expression Profiling Gene Expression Regulation, Neoplastic Genomics/*methods Humans Models, Biological Molecular Biology/methods Pheochromocytoma/genetics Tumor Markers, Biological/*analysis
Pubmed
Web of science
Création de la notice
15/02/2008 16:57
Dernière modification de la notice
20/08/2019 13:13
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