Molecular classification of T-cell lymphomas.
Détails
ID Serval
serval:BIB_2F1BA4F65769
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Molecular classification of T-cell lymphomas.
Périodique
Critical Reviews In Oncology/hematology
ISSN
1879-0461 (Electronic)
ISSN-L
1040-8428
Statut éditorial
Publié
Date de publication
2009
Volume
72
Numéro
2
Pages
125-143
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, Non-U.S. Gov't ; Review
Résumé
T-cell neoplasms encompass a heterogeneous group of relatively rare disease entities. This review, focused on lymphoblastic tumors (T-ALL/LBL) and nodal-based peripheral T-cell lymphomas (PTCL), summarizes recent advances in the molecular characterization of these diseases. In T-ALL/LBL, molecular subgroups delineated by gene expression profiling correlate with leukemic arrest at specific stages of normal thymocyte development and different oncogenic pathways, and seem to be of interest for prognosis prediction. Angioimmunoblastic T-cell lymphoma (AITL), one of the most common PTCL entities, comprises neoplastic cells with a molecular signature similar to normal follicular helper T cells, and this cellular derivation might account for several of the peculiar aspects of this disease. Except in ALK-positive anaplastic large cell lymphoma, defined by ALK gene fusions, chromosomal translocations are otherwise rare in PTCLs, but some recurrent rearrangements might be associated with distinct lymphoma subtypes. In PTCL, not otherwise specified (PTCL, NOS), novel molecular biomarkers of potential therapeutic interest have been recently identified.
Mots-clé
Gene Expression, Gene Expression Profiling, Humans, Lymphoma, T-Cell/classification, Lymphoma, T-Cell/genetics, Tumor Markers, Biological/genetics
Pubmed
Création de la notice
22/10/2010 13:57
Dernière modification de la notice
20/08/2019 13:13