Multi-ethnic fine-mapping of 14 central adiposity loci.
Détails
ID Serval
serval:BIB_2EF1B1D3F80C
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Multi-ethnic fine-mapping of 14 central adiposity loci.
Périodique
Human Molecular Genetics
Collaborateur⸱rice⸱s
African Ancestry Anthropometry Genetics Consortium, GIANT Consortium
Contributeur⸱rice⸱s
Liu CT., Monda KL., Taylor KC., Lange L., Demerath EW., Palmas W., Wojczynski MK., Ellis JC., Vitolins MZ., Liu S., Papanicolaou GJ., Irvin MR., Xue L., Griffin PJ., Nalls MA., Adeyemo A., Liu J., Li G., Ruiz-Narvaez EA., Chen WM., Chen F., Henderson BE., Millikan RC., Ambrosone CB., Strom SS., Guo X., Andrews JS., Sun YV., Mosley TH., Yanek LR., Shriner D., Haritunians T., Rotter JI., Speliotes EK., Smith M., Rosenberg L., Mychaleckyj J., Nayak U., Spruill I., Garvey W., Pettaway C., Nyante S., Bandera EV., Britton AF., Zonderman AB., Rasmussen-Torvik LJ., Chen YD., Ding J., Lohman K., Kritchevsky SB., Zhao W., Peyser PA., Kardia SL., Kabagambe E., Broeckel U., Chen G., Zhou J., Wassertheil-Smoller S., Neuhouser ML., Rampersaud E., Psaty B., Kooperberg C., Manson JE., Kuller LH., Ochs-Balcom HM., Johnson KC., Sucheston L., Ordovas JM., Palmer JR., Haiman CA., McKnight B., Howard BV., Becker DM., Bielak LF., Liu Y., Allison MA., Grant SF., Burke GL., Patel SR., Schreiner PJ., Borecki IB., Evans MK., Taylor H., Sale MM., Howard V., Carlson CS., Rotimi CN., Cushman M., Harris TB., Reiner AP., Cupples L., North KE., Fox CS., Heid IM., Jackson AU., Randall JC., Winkler TW., Qi L., Steinthorsdottir V., Thorleifsson G., Zillikens MC., Speliotes EK., Mägi R., Workalemahu T., White CC., Bouatia-Naji N., Harris TB., Berndt SI., Ingelsson E., Willer CJ., Weedon MN., Luan£££Jian'an£££ J. , Vedantam S., Esko£££Tõnu£££ T. , Kilpeläinen TO., Kutalik£££Zoltán£££ Z. , Li S., Monda KL., Dixon AL., Holmes CC., Kaplan LM., Liang L., Min JL., Moffatt MF., Molony C., Nicholson G., Schadt EE., Zondervan KT., Feitosa MF., Ferreira T., Lango Allen H., Weyant RJ., Wheeler E., Wood AR., Estrada K., Goddard ME., Lettre G., Mangino M., Nyholt DR., Purcell S., Smith AV., Visscher PM., Yang J., McCarroll SA., Nemesh J., Voight BF., Absher D., Amin N., Aspelund T., Coin L., Glazer NL., Hayward C., Heard-Costa NL., Hottenga JJ., Johansson£££Åsa£££ Å. , Johnson T., Kaakinen M., Kapur K., Ketkar S., Knowles JW., Kraft P., Kraja AT., Lamina C., Leitzmann MF., McKnight B., Morris AP., Ong KK., Perry JR., Peters MJ., Polasek O., Prokopenko I., Rayner NW., Ripatti S., Rivadeneira F., Robertson NR., Sanna S., Sovio U., Surakka I., Teumer A., van Wingerden S., Vitart V., Zhao JH., Cavalcanti-Proença C., Chines PS., Fisher E., Kulzer JR., Lecoeur C., Narisu N., Sandholt C., Scott LJ., Silander K., Stark K., Tammesoo ML., Teslovich TM., Timpson NJ., Watanabe RM., Welch R., Chasman DI., Cooper MN., Jansson JO., Kettunen J., Lawrence RW., Pellikka N., Perola M., Vandenput L., Alavere H., Almgren P., Atwood LD., Bennett AJ., Biffar R., Bonnycastle LL., Bornstein SR., Buchanan TA., Campbell H., Day IN., Dei M., Dörr M., Elliott P., Erdos MR., Eriksson JG., Freimer NB., Fu M., Gaget S., Geus EJ., Gjesing AP., Grallert H., Gräßler J., Groves CJ., Guiducci C., Hartikainen AL., Hassanali N., Havulinna AS., Herzig KH., Hicks AA., Hui J., Igl W., Jousilahti P., Jula A., Kajantie E., Kinnunen L., Kolcic I., Koskinen S., Kovacs P., Kroemer HK., Krzelj V., Kuusisto J., Kvaloy K., Laitinen J., Lantieri O., Lathrop GM., Lokki ML., Luben RN., Ludwig B., McArdle WL., McCarthy A., Morken MA., Nelis M., Neville MJ., Paré G., Parker AN., Peden JF., Pichler I., Pietiläinen KH., Platou CG., Pouta A., Ridderstråle M., Samani NJ., Saramies J., Sinisalo J., Smit JH., Strawbridge RJ., Stringham HM., Swift AJ., Teder-Laving M., Thomson B., Usala G., van Meurs JB. , van Ommen GJ. , Vatin V., Volpato CB., Wallaschofski H., Walters G., Widen E., Wild SH., Willemsen G., Witte DR., Zgaga L., Zitting P., Beilby JP., James AL., Kähönen M., Lehtimäki T., Nieminen MS., Ohlsson C., Palmer LJ., Raitakari O., Ridker PM., Stumvoll M., Tönjes A., Viikari J., Balkau B., Ben-Shlomo Y., Bergman RN., Boeing H., Smith GD., Ebrahim S., Froguel P., Hansen T., Hengstenberg C., Hveem K., Isomaa B., Jørgensen T., Karpe F., Khaw KT., Laakso M., Lawlor DA., Marre M., Meitinger T., Metspalu A., Midthjell K., Pedersen O., Salomaa V., Schwarz PE., Tuomi T., Tuomilehto J., Valle TT., Wareham NJ., Arnold AM., Beckmann JS., Bergmann S., Boerwinkle E., Boomsma DI., Caulfield MJ., Collins FS., Eiriksdottir G., Gudnason V., Gyllensten U., Hamsten A., Hattersley AT., Hofman A., Hu FB., Illig T., Iribarren C., Jarvelin MR., Kao WH., Kaprio J., Launer LJ., Munroe PB., Oostra B., Penninx BW., Pramstaller PP., Psaty BM., Quertermous T., Rissanen A., Rudan I., Shuldiner AR., Soranzo N., Spector TD., Syvanen AC., Uda M., Uitterlinden A., Völzke H., Vollenweider P., Wilson JF., Witteman JC., Wright AF., Abecasis GR., Boehnke M., Borecki IB., Deloukas P., Frayling TM., Groop LC., Haritunians T., Hunter DJ., Kaplan RC., North KE., O'Connell JR., Peltonen L., Schlessinger D., Strachan DP., Hirschhorn JN., Assimes TL., Wichmann HE., Thorsteinsdottir U., van Duijn CM. , Stefansson K., Cupples LA., Loos RJ., Barroso£££Inês£££ I. , McCarthy MI., Fox CS., Mohlke KL., Lindgren CM.
ISSN
1460-2083 (Electronic)
ISSN-L
0964-6906
Statut éditorial
Publié
Date de publication
2014
Peer-reviewed
Oui
Volume
23
Numéro
17
Pages
4738-4744
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: ppublish
Résumé
The Genetic Investigation of Anthropometric Traits (GIANT) consortium identified 14 loci in European Ancestry (EA) individuals associated with waist-to-hip ratio (WHR) adjusted for body mass index. These loci are wide and narrowing the signals remains necessary. Twelve of 14 loci identified in GIANT EA samples retained strong associations with WHR in our joint EA/individuals of African Ancestry (AA) analysis (log-Bayes factor >6.1). Trans-ethnic analyses at five loci (TBX15-WARS2, LYPLAL1, ADAMTS9, LY86 and ITPR2-SSPN) substantially narrowed the signals to smaller sets of variants, some of which are in regions that have evidence of regulatory activity. By leveraging varying linkage disequilibrium structures across different populations, single-nucleotide polymorphisms (SNPs) with strong signals and narrower credible sets from trans-ethnic meta-analysis of central obesity provide more precise localizations of potential functional variants and suggest a possible regulatory role. Meta-analysis results for WHR were obtained from 77 167 EA participants from GIANT and 23 564 AA participants from the African Ancestry Anthropometry Genetics Consortium. For fine mapping we interrogated SNPs within ± 250 kb flanking regions of 14 previously reported index SNPs from loci discovered in EA populations by performing trans-ethnic meta-analysis of results from the EA and AA meta-analyses. We applied a Bayesian approach that leverages allelic heterogeneity across populations to combine meta-analysis results and aids in fine-mapping shared variants at these locations. We annotated variants using information from the ENCODE Consortium and Roadmap Epigenomics Project to prioritize variants for possible functionality.
Pubmed
Web of science
Open Access
Oui
Création de la notice
22/01/2015 14:37
Dernière modification de la notice
20/08/2019 14:13
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