Envelope glycoprotein of arenaviruses.

Détails

Ressource 1Télécharger: BIB_2EC91B403AE6.P001.pdf (807.80 [Ko])
Etat: Public
Version: de l'auteur⸱e
ID Serval
serval:BIB_2EC91B403AE6
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Institution
Titre
Envelope glycoprotein of arenaviruses.
Périodique
Viruses
Auteur⸱e⸱s
Burri D.J., Palma J.R., Kunz S., Pasquato A.
ISSN
1999-4915 (Electronic)
ISSN-L
1999-4915
Statut éditorial
Publié
Date de publication
2012
Peer-reviewed
Oui
Volume
4
Numéro
10
Pages
2162-2181
Langue
anglais
Notes
WOS Document Type: Review
Résumé
Arenaviruses include lethal human pathogens which pose serious public health threats. So far, no FDA approved vaccines are available against arenavirus infections, and therapeutic options are limited, making the identification of novel drug targets for the development of efficacious therapeutics an urgent need. Arenaviruses are comprised of two RNA genome segments and four proteins, the polymerase L, the envelope glycoprotein GP, the matrix protein Z, and the nucleoprotein NP. A crucial step in the arenavirus life-cycle is the biosynthesis and maturation of the GP precursor (GPC) by cellular signal peptidases and the cellular enzyme Subtilisin Kexin Isozyme-1 (SKI-1)/Site-1 Protease (S1P) yielding a tripartite mature GP complex formed by GP1/GP2 and a stable signal peptide (SSP). GPC cleavage by SKI-1/S1P is crucial for fusion competence and incorporation of mature GP into nascent budding virion particles. In a first part of our review, we cover basic aspects and newer developments in the biosynthesis of arenavirus GP and its molecular interaction with SKI-1/S1P. A second part will then highlight the potential of SKI-1/S1P-mediated processing of arenavirus GPC as a novel target for therapeutic intervention to combat human pathogenic arenaviruses.
Pubmed
Web of science
Open Access
Oui
Création de la notice
20/12/2012 18:57
Dernière modification de la notice
20/08/2019 13:13
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