Transcriptional regulation of PIK3CA oncogene by NF-kappaB in ovarian cancer microenvironment.

Détails

ID Serval
serval:BIB_2EB64DC10214
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Transcriptional regulation of PIK3CA oncogene by NF-kappaB in ovarian cancer microenvironment.
Périodique
Plos One
Auteur(s)
Yang N., Huang J., Greshock J., Liang S., Barchetti A., Hasegawa K., Kim S., Giannakakis A., Li C., O'Brien-Jenkins A., Katsaros D., Bützow R., Coukos G., Zhang L.
ISSN
1932-6203 (Electronic)
ISSN-L
1932-6203
Statut éditorial
Publié
Date de publication
2008
Volume
3
Numéro
3
Pages
e1758
Langue
anglais
Notes
Publication types: Journal Article ; Research Support, N.I.H., Extramural ; Research Support, Non-U.S. Gov'tPublication Status: epublish
Résumé
PIK3CA upregulation, amplification and mutation have been widely reported in ovarian cancers and other tumors, which strongly suggests that PIK3CA is a promising therapeutic target. However, to date the mechanisms underlying PIK3CA regulation and activation in vivo is still unclear. During tumorigenesis, host-tumor interactions may play a critical role in editing the tumor. Here, we report a novel mechanism through which the tumor microenvironment activates the PIK3CA oncogene. We show that PIK3CA upregulation occurs in non-proliferating tumor regions in vivo. We identified and characterized the PIK3CA 5' upstream transcriptional regulatory region and confirmed that PIK3CA is transcriptionally regulated through NF-kappaB pathway. These results offer a new mechanism through which the tumor microenvironment directly activates oncogenic pathways in tumor cells.
Mots-clé
Base Sequence, DNA Primers, Electrophoretic Mobility Shift Assay, Female, Gene Expression Regulation, Enzymologic, Gene Expression Regulation, Neoplastic, Humans, Immunohistochemistry, In Situ Nick-End Labeling, NF-kappa B/metabolism, Ovarian Neoplasms/genetics, Phosphatidylinositol 3-Kinases/genetics, Transcription, Genetic
Pubmed
Web of science
Open Access
Oui
Création de la notice
14/10/2014 11:42
Dernière modification de la notice
20/08/2019 13:13
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