A New Twist on Radiation Oncology: Low-Dose Irradiation Elicits Immunostimulatory Macrophages that Unlock Barriers to Tumor Immunotherapy.

Détails

ID Serval
serval:BIB_2EACCCCDD646
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Editorial
Collection
Publications
Institution
Titre
A New Twist on Radiation Oncology: Low-Dose Irradiation Elicits Immunostimulatory Macrophages that Unlock Barriers to Tumor Immunotherapy.
Périodique
Cancer Cell
Auteur⸱e⸱s
De Palma M., Coukos G., Hanahan D.
ISSN
1878-3686 (Electronic)
ISSN-L
1535-6108
Statut éditorial
Publié
Date de publication
2013
Peer-reviewed
Oui
Volume
24
Numéro
5
Pages
559-561
Langue
anglais
Notes
Publication types: Journal Article Publication Status: ppublishDocument Type: Editorial Material
Résumé
Tumor-infiltrating macrophages typically promote angiogenesis while suppressing antitumoral T cell responses. In this issue of Cancer Cell, Klug and colleagues report that clinically-feasible, low-dose irradiation redirects macrophage differentiation from a tumor-promoting/immunosuppressive state to one that enables cytotoxic T cells to infiltrate tumors and kill cancer cells, rendering immunotherapy successful in mice.
Pubmed
Web of science
Open Access
Oui
Création de la notice
15/12/2013 15:51
Dernière modification de la notice
20/08/2019 13:13
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