Salivary alpha-amylase copy number is not associated with weight trajectories and glycemic improvements following clinical weight loss: results from a 2-phase dietary intervention study.

Détails

ID Serval
serval:BIB_2E940B39A73D
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Titre
Salivary alpha-amylase copy number is not associated with weight trajectories and glycemic improvements following clinical weight loss: results from a 2-phase dietary intervention study.
Périodique
The American journal of clinical nutrition
Auteur⸱e⸱s
Valsesia Armand, Kulkarni Sameer S., Marquis Julien, Leone Patricia, Mironova Polina, Walter Ondine, Hjorth Mads Fill, Descombes Patrick, Hager Jorg, Saris Wim H., Astrup Arne, Darimont Christian, O'Callaghan Nathan J.
Statut éditorial
Publié
Date de publication
04/2019
Volume
109
Numéro
4
Pages
1029-1037
Langue
anglais
Résumé
BACKGROUND: Several studies recently reported contradicting results regarding the link between amylase 1 (AMY1) copy numbers (CNs), obesity, and type 2 diabetes. OBJECTIVE: The aim of this study was to assess the impact of AMY1 CN on anthropometrics and glycemic outcomes in obese individuals following a 2-phase dietary weight loss intervention. METHODS: Using the paralog ratio test, AMY1 CNs were accurately measured in 761 obese individuals from the DiOGenes study. Subjects first underwent an 8-wk low-calorie diet (LCD, at 800 kcal/d) and then were randomly assigned to a 6-mo weight maintenance dietary (WMD) intervention with arms having different glycemic loads. RESULTS: At baseline, a modest association between AMY1 CN and BMI (P = 0.04) was observed. AMY1 CN was not associated with baseline glycemic variables. In addition, AMY1 CN was not associated with anthropometric or glycemic outcomes following either LCD or WMD. Interaction analyses between AMY1 CN and nutrient intake did not reveal any significant association with clinical parameters (at baseline and following LCD or WMD) or when testing gene x WMD interactions during the WMD phase. CONCLUSION: In the absence of association with weight trajectories or glycemic improvements, the AMY1 CN cannot be considered as an important biomarker for response to a clinical weight loss and weight maintenance programs in overweight/obese subjects. This trial was registered at www.clinicaltrials.gov as NCT00390637.
Mots-clé
Humans, Female, Gene Dosage, Male, * AMY1, *copy number, *insulin resistance, *low-calorie diet, *obesity, *weight loss, Adult, Body Weight, Body-Weight Trajectory, Caloric Restriction, Glycemic Load, Middle Aged, Obesity/*diet therapy/enzymology/*genetics/physiopathology, Salivary alpha-Amylases/*genetics/metabolism, Weight Loss
Pubmed
Création de la notice
19/02/2020 12:23
Dernière modification de la notice
19/06/2020 5:26
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