Systemic strongyloidiasis is a rare but serious complication of intestinal strongyloidiasis. This condition occurs mainly in immunosuppressed patients and has a significant mortality rate. The use of immunosuppressive and cytotoxic treatment has increased its incidence. A better awareness of this infection with early diagnosis and treatment is essential. We report two cases of strongyloidiasis. The first, uncomplicated intestinal strongyloidiasis occurred in a 32-year-old HIV-positive women. The second case was fatal disseminated strongyloidiasis in a 14-year-old child who underwent prior surgery and radiotherapy with cortico sterpoid therapy for a malignant brain ganglioglioma. The pathological basis of intestinal and disseminated strongyloidiasis are discussed