Androgens and the brain.

Détails

ID Serval
serval:BIB_2E67F64DBAEE
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Androgens and the brain.
Périodique
Maturitas
Auteur⸱e⸱s
Genazzani A.R., Pluchino N., Freschi L., Ninni F., Luisi M.
ISSN
0378-5122 (Print)
ISSN-L
0378-5122
Statut éditorial
Publié
Date de publication
20/05/2007
Peer-reviewed
Oui
Volume
57
Numéro
1
Pages
27-30
Langue
anglais
Notes
Publication types: Journal Article ; Review
Publication Status: ppublish
Résumé
Steroids arriving from the gonads via the circulation modulate brain function, affecting gender differentiation and sexually differentiated behavioral responses, but also the ability of the brain to process, store and retrieve sensory information. Androgens play a pivotal neuroactive role during the "organizational/developmental" phase, mainly in the fetal-neonatal period, when participated to the formation of neuronal circuits, as well as during the aging process when it has been demonstrated to directly affect hippocampal spine synapse density, suggesting a physiopathological role for androgen in the modulation cognitive function and development of neurodegenerative disease. The present short review will focus on the neuroactive effect of androgen with particular regard to the Delta4 and Delta5 androgen replacement therapy.
Mots-clé
Aging, Androgens/metabolism, Animals, Brain/drug effects, Brain/physiology, Dehydroepiandrosterone/pharmacology, Dehydroepiandrosterone/physiology, Female, Haplorhini, Hormone Replacement Therapy/methods, Humans, Postmenopause/drug effects, Postmenopause/physiology, Postmenopause/psychology, Rats
Pubmed
Web of science
Création de la notice
15/09/2023 12:25
Dernière modification de la notice
27/09/2023 6:39
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