Le processus d'exocytose lysosomale localisee est-il responsable de l'action cytolytique des lymphocytes T tuers? [Is the process of localized lysosomal exocytosis responsible for the cytolytic action of killer T-lymphocytes?]

Détails

ID Serval
serval:BIB_2E172A787E38
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Le processus d'exocytose lysosomale localisee est-il responsable de l'action cytolytique des lymphocytes T tuers? [Is the process of localized lysosomal exocytosis responsible for the cytolytic action of killer T-lymphocytes?]
Périodique
Comptes Rendus des Seances de l'Academie des Sciences. Serie D, Sciences Naturelles
Auteur⸱e⸱s
David  A., Bernard  J., Thiernesse  N., Nicolas  G., Cerottini  J. C., Zagury  D.
ISSN
0567-655X (Print)
Statut éditorial
Publié
Date de publication
01/1979
Volume
288
Numéro
4
Pages
441-4
Notes
English Abstract
Journal Article --- Old month value: Jan 29
Résumé
In this paper, we formulate the hypothesis that in the process of target cell lysis a lysosomal enzyme regurgitation, performed by killer cells at the level of the target effector junction, accounts for the target lesion which precedes the lysis (lethal hit). This process of exocytosis, similar to the one described previously in polymorphonuclear neutrophils is supported by cytological studies performed directly on identified killers isolated by micromanipulation. Light and electron microscopy observations confirm a previous report which describes the effector cells rich in lysosomal bodies. In addition, when a killer cell is associated with a target cell to form a conjugate, lysosomes are concentrated near the cell junction and, after incubation at 37 degrees C, acid phosphatases may be detected at the junction. Lysosomal enzyme exocytosis explains why target lysis needs an effector target binding to occur and also the other conditions required for any exocytosis process such as Ca++ in the medium, integrity of the microtubular apparatus, a low level of cyclic AMP and energy dependancy.
Mots-clé
Acid Phosphatase/*metabolism Animals *Exocytosis Killer Cells/*enzymology/ultrastructure Lysosomes/*enzymology/ultrastructure Mice Mice, Inbred BALB C Mice, Inbred Strains Microscopy, Electron T-Lymphocytes/*enzymology/ultrastructure
Pubmed
Web of science
Création de la notice
28/01/2008 12:14
Dernière modification de la notice
20/08/2019 14:12
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