Oscillatory brain dynamics supporting impaired Stroop task performance in schizophrenia-spectrum disorder.

Détails

ID Serval
serval:BIB_2DF6EEA24A10
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Oscillatory brain dynamics supporting impaired Stroop task performance in schizophrenia-spectrum disorder.
Périodique
Schizophrenia research
Auteur(s)
Popov T., Kustermann T., Popova P., Miller G.A., Rockstroh B.
ISSN
1573-2509 (Electronic)
ISSN-L
0920-9964
Statut éditorial
Publié
Date de publication
02/2019
Peer-reviewed
Oui
Volume
204
Pages
146-154
Langue
anglais
Notes
Publication types: Journal Article
Publication Status: ppublish
Résumé
The Stroop color-word interference task, prompting slower response to color-incongruent than to congruent items, is often used to study neural mechanisms of inhibitory control and dysfunction in schizophrenia-spectrum disorders. Inconsistent findings of an augmented Stroop effect limit identification of relevant dysfunctional mechanism(s) in schizophrenia. The present study sought to advance understanding of normal and impaired neural oscillatory dynamics by distinguishing interference detection and response preparation during the Stroop task in schizophrenia-spectrum disorders via analysis of behavioral performance and 4-7 Hz (theta) and 10-30 Hz (alpha/beta) EEG oscillations in 40 patients (SZ) and 27 healthy comparison participants (HC). SZ responded more slowly and showed less dorsal anterior cingulate (dACC) theta enhancement during INC trials, less enhancement of dACC-sensorimotor cortex connectivity (theta phase synchrony) during INC trials, more alpha/beta suppression though less enhancement of that suppression during INC trials, and slower post-response alpha/beta rebound than did HC. Reaction time distributions showed larger group and Stroop effects during the 25% of trials with the slowest responses. Poorer theta phase coherence in patients indicates impaired communication between regions associated with interference processing (dACC) and response preparation (sensorimotor cortex). Results suggest a failure cascade in which compromised behavioral Stroop effects are driven at least in part by dysfunctional interference processing (less theta power increase) prompting dysfunctional motor response preparation (less alpha/beta power suppression). Inconsistent Stroop effects in past studies of schizophrenia may result from differing task parameters sampling different degrees of Stroop task difficulty.
Mots-clé
Brain oscillations, Connectivity, Electroencephalogram, Reaction time, Schizophrenia, Stroop task
Pubmed
Web of science
Création de la notice
03/09/2018 13:57
Dernière modification de la notice
20/08/2019 14:12
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