Use of combination therapy is associated with improved LDL cholesterol management: 1-year follow-up results from the European observational SANTORINI study.
Détails
Etat: Public
Version: Final published version
Licence: CC BY 4.0
ID Serval
serval:BIB_2DE5249F1EBE
Type
Article: article d'un périodique ou d'un magazine.
Collection
Publications
Institution
Titre
Use of combination therapy is associated with improved LDL cholesterol management: 1-year follow-up results from the European observational SANTORINI study.
Périodique
European journal of preventive cardiology
Collaborateur⸱rice⸱s
SANTORINI Study Investigators
Contributeur⸱rice⸱s
Toplak H., Hengstenberg C., Clodi M., Ludvik B., Ebenbichler C., Schernthaner G.H., Hanusch U., Auer J., Schober A., Alber H., Zirlik A., Fließer-Görzer E., Maca T., Sock R., Stulnig T., Weitgasser R., Kober A., Gelsinger C., Demeure F., Calozet Y., Cools F., Sarens T., Versyck P., Vanstechelman F., Capiau L., Dujardin K., Vanduynhoven P., Heyse A., Janssens L., De Man F., Elegeert I., Roelandt R., Evrard P., Maamar R., Van De Borne P., Vandekerckhove H., Decaluwe E., Cosyns B., Descamps O., Pieters D., Hollanders G., Catez E., De Wolf A., Rietzschel E., Xaplanteris P., Hildebrandt R., Kofod Lindhardt M., Iversen H.K., Gislason G., Schultz A.Ø., Lomholdt J., Christensen H.K., Thomsen K., Heitmann M., Broennum-Schou J., Galatius S., Tuxen C., Strandberg T., Sulosaari S., Näppi S., Nyman K., Abraham M., Kantola I., Kekki S., Averson K., Hukkanen J., Korsoff P., Lagerstedt A., Taurio J., Valkama N., Hartikainen J., Häggman V.M., Risku S., Syvänne M., Paul R., Hietanen H., Strandberg A., Talka J., Aaltokallio T., Delarche N., Fayard M., Cohen S., Ferrari E., Ghanem F., Dassa G., Lenestour J., Labeque J.N., Decoulx E., Caze B., Lemesle G., Delorme L., Bouleti C., Razafy J., Azzano O., Rochette G.B., Tartiere J.M., Montalescot G., Cayla G., Berland J., Caudmont S., Solanet R., Boccara F., Andarelli J.N., Levy G., Troussard V., Mingam S., Poulain F., Probst V., Furber A., Cariou B., Range G., Audonnet M., Clerc J., Lemercier T., Mouret J.P., Rachenne D., Lesault P.F., Zeghidi B., Ferrieres J., Broucqsault D., Duroy C., Aboyans V., Stephan D., Laufs U., Simonis G., Schaper F., Schatz U., Ebert H.H., Axthelm C., Oettler W., Weißbrodt M., Grebe E., Wittig I., Spens A., Taggeselle J., Spengler U., Hagenow A., Schlitt A., Menzel F., Langel J., Gerth J., Leißring A., Enders D., Stellmach H., Kassner U., Rieker W.A., Zemmrich C., Claus M., Winkelmann A., Behrens S., Vogtmann T., Wolf U., Ritter O., Rother M., Ince H., Prophet H., Subin B., Paitazoglou C., Twisselmann T., Schofer J., Wilke A., Denchev D., Gercek M., Gerbaulet U., Gielen S., Götte A., Appel K.F., Simon J., Gollisch K., Baar M., Stratmann M., Dyckmanns N., Wetzel T., Schütz B., Schaefer A., Haj-Yehia A., Rose L., Fechtrup C., Gebauer K., Meyer S., Klutmann M., Schmidt-Reinwald A., Werner N., Zotz R., Espinola-Klein C., Wild P., Genth-Zotz S., Krämer F., Horacek T., Mitrovic V., Jungmair W., Hintze J., Steiner S., Kadel C., Wolf J., Lißmann J., Böhm M., Hammer B., Bruck K., Süselbeck T., Killat H., Schirmer S., Salbach P., Stach K., Erbel C., Korosoglou G., Scheuermann O., Bosch R., Blessing E., Hardt S., Leggewie S., Schmid M., Methe H., Hahmann H.W., Jahnke N., Stadelmann A., Jeserich M., Haas J., Schnupp S., Herrmann P., Fassnacht-Capeller M., Schermaul K.H., Naumann R., Ernstberger J., Retkowska M., Jacob S., Hamann F., Delonge M., El-Meadawy S., Hellhammer K., Eberhard K., Köhrmann M., Waessnig N., Buresch M., Osterziel K.J., Olesch E., Jung J., Voigt A., Predel D., Scholle J.E., Schiffer C., Lukannek S., Simon-Wagner I., Methfessel H., Allers A., Braun H., Schwarz T., Täschner H., Schulz S., Brado B., Zandt D., Birkenhagen A., Woitek C., Varnai G., Hartung W., Schwabe K., Schreckenberg A., Warzok F., Coban N., Prohaska M., Durak M., Gysan D., Zarse M., Bogossian H., Ben-Chur R., Walter T., Hansen S., Ohler H.J., Krapivsky A., Arca M., Pirro M., Giorgino F., Suppressa P., Cipollone F., Ferri C., Desideri G., Alberghini E., Di Minno M., Mauro C., Lupoli R., Pipolo A., Lococo M., Feola M., Averna M., Licciardello G., Marcucci R., Borghi C., Catalini R., Guerra F., Sarzani R., Nassiacos D., Campo G.C., Imbalzano E., Lucchi T.A., Pellicano M., Casella G., Repetti E., Clemente M.A., Di Natale M., De Ferrari G., Brunetti N.D., Esposito G., Fazio G., Calabrò P., Carbonare L.D., Alberti A., Mannucci E., Gnasso A., Andò G., Amico F., Novo G., Alessandri M., Di Lenarda A., Sampietro T., Gonnelli S., D'amario D., Bilato C., Pisciotta L., Montalcini T., Golino P., Scherillo M., Boriani G., Luzzi G., Indolfi C., Mazzarino S., Mugnolo A., Gorga E., Fiorentini A., Parodi G., De Caterina R., Muiesan M.L., Andreini D., Navazio A., Straniti M., Del Ben M., Carubbi F., Aschieri D., Fresco C., Grimaldi M., Werba J.P., Trevisan R., Nicosia A., Mor D.A., Di Lorenzo E., Di Belardino N., Passaro A., Solini A., Lanzilli A., Salvatore V., Colonna G., Lupi A., Di Mario C., Di Lorenzo L., Jacomelli I., Paternò G., Mandraffino G., Tortorella G., Focardi M., De Blasio G., Vespucci C., Cemin R., Ferdenzi E., Filippucci L., Grigore L., Maroni L., Midi P., Sesti G., Di Vincenzo E., Prati F., Comito M., Sciahbasi A., Bui F., Grigioni F., Tortorici G., Sollazzo V., Becirovic M., Caramanno G., Branchi A., Manfellotto D., Menghini F., Galiè N., Puato M., Visonà A., Sarullo F., Vecchione C., Marfella R., Dell'elce A., Nicolino A., Van Eck M., Linssen G., Hamer B., Groenemeijer B., Beelen D., Asselman M., Arkenbout K., Drost J., Martens F., De Nooijer C., Schellings D., Zoet-Nugteren S., Visseren F., Aksoy I., Jukema W., Van Ofwegen-Hanekamp C., Constandse J., Oosterhof T., Dijkmans P., Van Es R., Kuijper A., Haasdijk A., Viergever E., Van Etten J., Van Der Zee M., Hermans W., Meijs M., Wu K.W., Van De Wal R., Aguiar C., Monteiro P., Mimoso J., Duarte J.S., Pinto F., Aguiar P., Raposo J., Pinto F., Carvalho D., Von Hafe P., Alves P., Sheahan R., Murphy R., Burke D., Mcfadden E., Byrne R., Nolan D., Mostaza J.M., Lahoz C., Chinchurreta P., Pinal I., Martínez-Sellés M., Villardón B.P., Ortiz L.G., Freire S.C., García J.C., Del Egido A.G., Acea AMB, Bermudez M.G., Muñóz JLM, Valdivieso P., Muñoz C.P., León J., Sala J.P., Jimenez MJR, Campal JMR, Velásques E., Romero AJF, Suarez S., Gómez Peralta F., Sala X.P., Pérez V.E., Gutierrez A.I., Quiñones O., Miranda C.A., Aracil J., Olivo C., Belloso I., Delgado F.G., Arguero V.L., Montoya JPB, Figal D.P., Menchero A.G., Domenech M., Rodríguez R.S., Ruiz IME, Pérez A., Encabo R.O., Talavera P., Blanco E., Manterola F.A., Fernández J., Arrobas T., Escobar C., Plana N., Manzano L., Polo I.G., Diaz JLD, Mañero M.R., Bustillo S.R., De Dios García Diaz J., Herraiz C.G., Murillo F.C., Debén F.M., De Isla L.P., García JDM, Marin JCP, De Yébenes Castro M.G., Marazuela M., Simó R., Montesinos R.R., De Paz I.P., Abreu C.G., Roy Á.G., Cañas R.A., Jericó C., Zamorano J.L., Collado A.E., Espiga Alzola J., Hernandez Hernandez J.L., Cerezo JFG, Echevarría A.B., Quintana A.G., Esteban A., Tembra M.S., Freire S., Eriksson M., Lindholm C.J., Sloma A., Gottsäter A., Romeo S., Dellborg M., Witt N., Barmano N., Hallgren P., Salmonsson S., Milonas C., Nanchen D., Koskinas K., Ehret G., Sudano I., Müller C., Egloff M., Bilz S., Wyss C., Miserez A.R., Cuculi F., Bosquet S., Rudofsky G., Romanens M., Mullick S.P., Mcnally D., Gunstone A., Ryan J., Garstang J., Jacobsen N., Moriarty A., Turner W., Mccormack T., Johnson T., Capehorn M., Schramm C., Guyler P., Narayanan D., Toms G., Ainsworth P., Ikpoh M., Fuat A., Dickson J., Capps N., Viswanathan K., Pattman S., Balakrishnan-Nair S., Gbegbaje A., Saxena M., Keast C., Browne D., Zafar A., Lip G., Moore P., Fisher S., Fisher S., Fisher S., Powell G., Sevenoaks T., Hyde T., Carey P., Butler M., Evbuomwan C., Thiagu S., Schofield I., Irvine G., Kamali F., Hughes S., Wakeling J., Mullick S.P., Ray K.K., Catapano A.L., Aguiar C., Arca M., Connolly D.L., Eriksson M., Ferrières J., Hildebrandt P., Laufs U., Mostaza J.M., Nanchen D., Rietzschel E., Strandberg T., Toplak H., Visseren FLJ
ISSN
2047-4881 (Electronic)
ISSN-L
2047-4873
Statut éditorial
Publié
Date de publication
11/11/2024
Peer-reviewed
Oui
Volume
31
Numéro
15
Pages
1792-1803
Langue
anglais
Notes
Publication types: Journal Article ; Observational Study ; Multicenter Study
Publication Status: ppublish
Publication Status: ppublish
Résumé
To assess whether implementation of the 2019 European Society of Cardiology (ESC)/European Atherosclerosis Society (EAS) dyslipidaemia guidelines observed between 2020 and 2021 improved between 2021 and 2022 in the SANTORINI study.
Patients with high or very high cardiovascular (CV) risk were recruited across 14 European countries from March 2020 to February 2021, with 1-year prospective follow-up until May 2022. Lipid-lowering therapy (LLT) and 2019 ESC/EAS risk-based low-density lipoprotein (LDL) cholesterol (LDL-C) goal attainment (defined as <1.4 mmol/L for patients at very high CV risk and <1.8 mmol/L for patients at high CV risk) at 1-year follow-up were compared with baseline. Of 9559 patients enrolled, 9136 (2626 high risk and 6504 very high risk) had any available follow-up data, and 7210 (2033 high risk and 5173 very high risk) had baseline and follow-up LDL-C data. Lipid-lowering therapy was escalated in one-third of patients and unchanged in two-thirds. Monotherapy and combination therapy usage rose from 53.6 and 25.6% to 57.1 and 37.9%, respectively. Mean LDL-C levels decreased from 2.4 to 2.0 mmol/L. Goal attainment improved from 21.2 to 30.9%, largely driven by LLT use among those not on LLT at baseline. Goal attainment was greater with combination therapy compared with monotherapy at follow-up (39.4 vs. 25.5%).
Lipid-lowering therapy use and achievement of risk-based lipid goals increased over 1-year follow-up particularly when combination LLT was used. Nonetheless, most patients remained above goal; hence, strategies are needed to improve the implementation of combination LLT.
Patients with high or very high cardiovascular (CV) risk were recruited across 14 European countries from March 2020 to February 2021, with 1-year prospective follow-up until May 2022. Lipid-lowering therapy (LLT) and 2019 ESC/EAS risk-based low-density lipoprotein (LDL) cholesterol (LDL-C) goal attainment (defined as <1.4 mmol/L for patients at very high CV risk and <1.8 mmol/L for patients at high CV risk) at 1-year follow-up were compared with baseline. Of 9559 patients enrolled, 9136 (2626 high risk and 6504 very high risk) had any available follow-up data, and 7210 (2033 high risk and 5173 very high risk) had baseline and follow-up LDL-C data. Lipid-lowering therapy was escalated in one-third of patients and unchanged in two-thirds. Monotherapy and combination therapy usage rose from 53.6 and 25.6% to 57.1 and 37.9%, respectively. Mean LDL-C levels decreased from 2.4 to 2.0 mmol/L. Goal attainment improved from 21.2 to 30.9%, largely driven by LLT use among those not on LLT at baseline. Goal attainment was greater with combination therapy compared with monotherapy at follow-up (39.4 vs. 25.5%).
Lipid-lowering therapy use and achievement of risk-based lipid goals increased over 1-year follow-up particularly when combination LLT was used. Nonetheless, most patients remained above goal; hence, strategies are needed to improve the implementation of combination LLT.
Mots-clé
Humans, Cholesterol, LDL/blood, Male, Female, Europe, Middle Aged, Dyslipidemias/drug therapy, Dyslipidemias/blood, Dyslipidemias/epidemiology, Dyslipidemias/diagnosis, Aged, Prospective Studies, Drug Therapy, Combination, Follow-Up Studies, Time Factors, Cardiovascular Diseases/prevention & control, Cardiovascular Diseases/blood, Cardiovascular Diseases/epidemiology, Biomarkers/blood, Treatment Outcome, Hydroxymethylglutaryl-CoA Reductase Inhibitors/therapeutic use, Practice Guidelines as Topic, Heart Disease Risk Factors, Hypolipidemic Agents/therapeutic use, Risk Assessment, Guideline Adherence, Anticholesteremic Agents/therapeutic use, Cardiovascular risk, Dyslipidaemia, Lipid, Real-world clinical trials
Pubmed
Open Access
Oui
Création de la notice
14/06/2024 15:24
Dernière modification de la notice
19/11/2024 7:23
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