Gibt es tumorbiologische Besonderheiten, die ein bevorzugtes Auftreten von Rezidiven bei Kopf-Hals-Tumoren begünstigen: Tumorinvasion "revisited" [What makes "Head-and-Neck-Cancers" recur: Tumorinvasion "revisited"].

Détails

ID Serval
serval:BIB_2DC6744BF0B3
Type
Article: article d'un périodique ou d'un magazine.
Sous-type
Synthèse (review): revue aussi complète que possible des connaissances sur un sujet, rédigée à partir de l'analyse exhaustive des travaux publiés.
Collection
Publications
Titre
Gibt es tumorbiologische Besonderheiten, die ein bevorzugtes Auftreten von Rezidiven bei Kopf-Hals-Tumoren begünstigen: Tumorinvasion "revisited" [What makes "Head-and-Neck-Cancers" recur: Tumorinvasion "revisited"].
Périodique
Laryngo-Rhino-Otologie
Auteur(s)
Simon C., Koitschev A., Plinkert P.K.
ISSN
0935-8943 (Print)
ISSN-L
0935-8943
Statut éditorial
Publié
Date de publication
2007
Volume
86
Numéro
3
Pages
172-175
Langue
allemand
Notes
Publication types: English Abstract ; Journal Article ; Research Support, Non-U.S. Gov't ; ReviewPublication Status: ppublish
Résumé
Head and neck squamous cell carcinomas (HNSCC) are common cancers with a relatively poor prognosis. Locoregionale recurrences are regularly encountered and associated with a detrimental outcome. Studies of the last few years report that not only tumor staging and grading influence locoregional control but also histologic and biological markers. One such histological marker is coined "worst pattern of invasion". It describes a histologic growth pattern consisting of invading tumor cell islands and strands that are dispatched from the invasion front (POI typ 4 and 5). Additional features of invasion are perineural invasion and extracapsular nodal extension. Besides histological markers there are molecular characteristics that include the expression of gene families involved in extracellular matrix degradation. The data suggest that head and neck cancers differ with respect to their invasive growth capacity and thus their ability to generate locoregionale recurrences. It appears that locoregionale control is a consequence of this growth pattern. This may explain, why in recent clincial studies the prognostic marker "pattern-of-invasion" outweights even such well established prognosticators such as "surgical margins".
Mots-clé
Adult, Carcinoma, Squamous Cell/epidemiology, Carcinoma, Squamous Cell/genetics, Carcinoma, Squamous Cell/radiotherapy, Combined Modality Therapy, Head and Neck Neoplasms/epidemiology, Head and Neck Neoplasms/genetics, Head and Neck Neoplasms/radiotherapy, Humans, Neoplasm Recurrence, Local/pathology, Neoplasm Staging, Prognosis, Radiotherapy, Adjuvant, Risk Factors
Pubmed
Web of science
Création de la notice
21/01/2013 16:13
Dernière modification de la notice
20/08/2019 14:12
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